Vangl2 - VANGL planar cell polarity 2 Gene

Also Known as Lp; Lpp1; Ltap; stbm; Lootl; ska17; Vang1l2; loop-tail; strabismus; ska; C530001F03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 93840

Summary

Involved in axon guidance; cell migration involved in kidney development; and morphogenesis of an epithelium. Acts upstream of or within several processes, including animal organ development; morphogenesis of an epithelium; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neural ectoderm; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Vangl2 Products (1)

mRNA Protein Name
NM_033509.4 NP_277044.1 vang-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15195140 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
16116426 MGI
involved in Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
18849982 MGI
acts upstream of or within apical protein localization IMP
IMP: Inferred from mutant phenotype
16495441 MGI
involved in cell migration involved in kidney development IMP
IMP: Inferred from mutant phenotype
20534871 MGI
acts upstream of or within cochlea development IGI
IGI: Inferred from genetic interaction
18066062 MGI
acts upstream of or within cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
16116426 MGI
acts upstream of or within convergent extension involved in axis elongation IMP
IMP: Inferred from mutant phenotype
17229766 MGI
acts upstream of or within convergent extension involved in neural plate elongation IGI
IGI: Inferred from genetic interaction
16571627 MGI
acts upstream of or within convergent extension involved in neural plate elongation IMP
IMP: Inferred from mutant phenotype
16571627 MGI
acts upstream of or within convergent extension involved in organogenesis IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within digestive tract morphogenesis IGI
IGI: Inferred from genetic interaction
19300477 MGI
involved in dopaminergic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within establishment of body hair planar orientation IMP
IMP: Inferred from mutant phenotype
18849982 MGI
acts upstream of or within establishment of planar polarity IGI
IGI: Inferred from genetic interaction
20643356 MGI
involved in establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
12724779 MGI
acts upstream of or within establishment of planar polarity involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
18606138 MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
17376975 MGI
acts upstream of or within glomerulus development IMP
IMP: Inferred from mutant phenotype
20843830 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
18849982 MGI
involved in heart looping IMP
IMP: Inferred from mutant phenotype
11440971 MGI
acts upstream of or within heparan sulfate proteoglycan biosynthetic process IMP
IMP: Inferred from mutant phenotype
23760952 MGI
acts upstream of or within inner ear receptor cell development IGI
IGI: Inferred from genetic interaction
20940229 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
18066062 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
18606138 MGI
acts upstream of or within kidney morphogenesis IMP
IMP: Inferred from mutant phenotype
20843830 MGI
acts upstream of or within lateral sprouting involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within membranous septum morphogenesis IGI
IGI: Inferred from genetic interaction
20940229 MGI
acts upstream of or within muscular septum morphogenesis IGI
IGI: Inferred from genetic interaction
20940229 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
14512015 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
11709546 MGI
acts upstream of or within non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19497282 MGI
acts upstream of or within non-motile cilium assembly IGI
IGI: Inferred from genetic interaction
16170314 MGI
acts upstream of or within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within positive regulation of JUN kinase activity IGI
IGI: Inferred from genetic interaction
15195140 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
21761479 MGI
acts upstream of or within regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
24302887 MGI
acts upstream of or within regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20223754 MGI
acts upstream of or within regulation of establishment of planar polarity IGI
IGI: Inferred from genetic interaction
19300477 MGI
involved in regulation of synapse pruning IDA
IDA: Inferred from direct assay
34407949 MGI
involved in regulation of synapse pruning IMP
IMP: Inferred from mutant phenotype
34407949 MGI
involved in serotonergic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within somatic stem cell division IMP
IMP: Inferred from mutant phenotype
19497282 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19497282 MGI
acts upstream of or within wound healing IGI
IGI: Inferred from genetic interaction
20643356 MGI
Cellular Component GO Annotation Evidence References Source
located in COPII-coated ER to Golgi transport vesicle IDA
IDA: Inferred from direct assay
19966784 MGI
located in apical cytoplasm IDA
IDA: Inferred from direct assay
25333478 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16687519 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
20534871 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
20215345 MGI
located in cell pole IDA
IDA: Inferred from direct assay
19497282 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
15195140 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34407949 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
17433286 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16962386 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
34407949 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
24302887 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vang-like protein 2

  • loop tail associated protein

  • loop-tail protein 1

  • van Gogh-like protein 2

  • vang-like 2 (van gogh, Drosophila)

Vangl2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Vangl2 Q91ZD4 Dvl1 Mus musculus P51141
Pull Down
15456783
Intra
Vangl2 Q91ZD4 Dvl3 Mus musculus Q61062
Y2H
15456783
Intra
Vangl2 Q91ZD4 Dvl3 Mus musculus Q61062
Pull Down
15456783
Intra
Vangl2 Q91ZD4 Dact1 Mus musculus Q8R4A3
Anti Tag CoIP
19701191
Intra
Vangl2 Q91ZD4 Dvl2 Mus musculus Q60838
Pull Down
15456783
Intra
Vangl2 Q91ZD4 Dvl2 Mus musculus Q60838
Anti Bait CoIP
15456783
Intra
Vangl2 Q91ZD4 Dvl2 Mus musculus Q60838
Anti Tag CoIP
19701191
Cross
Vangl2 Q91ZD4 Dlg4 Rattus norvegicus P31016
Pull Down
23567299
Cross
Vangl2 Q91ZD4 Dlg4 Rattus norvegicus P31016
Anti Tag CoIP
23567299
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS15601 VANGL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21218 Vangl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27734 Vangl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vangl2 NCBI NCBI:57216