Dact1 - dishevelled-binding antagonist of beta-catenin 1 Gene

Also Known as Frd1; FRODO; MDpr1; MTNG3; DAPPER; Frodo1; THYEX3; DAPPER1; 4921528D17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59036

Summary

Enables delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in embryonic hindgut morphogenesis and regulation of signal transduction. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of canonical Wnt signaling pathway; and positive regulation of fat cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dact1 Products (2)

mRNA Protein Name
NM_001190466.1 NP_001177395.1 dapper homolog 1 isoform 1
NM_021532.4 NP_067507.2 dapper homolog 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables delta-catenin binding IDA
IDA: Inferred from direct assay
21718540 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11970895 MGI
enables protein kinase A binding IDA
IDA: Inferred from direct assay
21718540 MGI
enables protein kinase C binding IDA
IDA: Inferred from direct assay
21718540 MGI
Biological Process GO Annotation Evidence References Source
NOT involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20145239 MGI
acts upstream of or within dendrite morphogenesis IGI
IGI: Inferred from genetic interaction
20335472 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
20335472 MGI
involved in embryonic hindgut morphogenesis IMP
IMP: Inferred from mutant phenotype
20145239 MGI
acts upstream of or within embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
19701191 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
19701191 MGI
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
17197390 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
17197390 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19073771 MGI
acts upstream of or within positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
19073771 MGI
acts upstream of or within regulation of Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
19701191 MGI
involved in regulation of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
20145239 MGI
NOT involved in regulation of nodal signaling pathway IDA
IDA: Inferred from direct assay
17197390 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
20335472 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
20335472 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
20335472 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20335472 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
20335472 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20335472 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
20335472 MGI
is active in postsynapse IEP
IEP: Inferred from expression pattern
20335472 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dapper homolog 1

  • dapper 1

  • dapper antagonist of catenin 1

  • dapper homolog 1, antagonist of beta-catenin

  • frodo homolog

  • thymus expressed gene 3

  • thymus-expressed novel gene 3 protein

Dact1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dact1 Q8R4A3 Dvl1 Mus musculus P51141
Pull Down
14636582
Intra
Dact1 Q8R4A3 Dvl1 Mus musculus P51141
Anti Tag CoIP
21718540
Intra
Dact1 Q8R4A3 Dvl1 Mus musculus P51141
Fluorescence Spectr
14636582
Intra
Dact1 Q8R4A3 Vangl2 Mus musculus Q91ZD4
Anti Tag CoIP
21718540
Intra
Dact1 Q8R4A3 Vangl2 Mus musculus Q91ZD4
Pull Down
19701191
Intra
Dact1 Q8R4A3 Dact3 Mus musculus Q0PHV7
Anti Tag CoIP
21718540
Intra
Dact1 Q8R4A3 Dvl2 Mus musculus Q60838
Anti Tag CoIP
19701191
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03515 DACT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dact1 NCBI NCBI:51339