Dact3 - dishevelled-binding antagonist of beta-catenin 3 Gene

Also Known as naa-3; EG666671

Species: Mus musculus

Gene Type: protein coding

Gene ID: 629378

Summary

Enables several functions, including delta-catenin binding activity; identical protein binding activity; and protein kinase C binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and negative regulation of epithelial to mesenchymal transition. Located in cytoplasm. Is expressed in several structures, including branchial arch artery; central nervous system; embryo mesenchyme; genitourinary system; and tooth. Orthologous to human DACT3 (dishevelled binding antagonist of beta catenin 3). [provided by Alliance of Genome Resources, Apr 2022]

Dact3 Products (1)

mRNA	Protein	Name
NM_001081655.1	NP_001075124.1	dapper homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables delta-catenin binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	21718540	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21718540	MGI
enables protein kinase A binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables protein kinase C binding	IDA IDA: Inferred from direct assay	21718540	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	23580654	MGI
acts upstream of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	23580654	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	23580654	MGI
acts upstream of or within negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	23580654	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23580654	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dapper homolog 3	dact 3 dapper antagonist of catenin 3 dapper homolog 3, antagonist of beta-catenin

Dact3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dact3	Q0PHV7	Dact1	Mus musculus	Q8R4A3	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Dact2	Mus musculus	Q7TN08	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Dact3	Mus musculus	Q0PHV7	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Dvl3	Mus musculus	Q61062	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Ctnnb1	Mus musculus	Q02248	Anti Bait CoIP	21718540
Intra	Dact3	Q0PHV7	Vangl2	Mus musculus	Q91ZD4	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Dvl1	Mus musculus	P51141	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Vangl1	Mus musculus	Q80Z96	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Dvl2	Mus musculus	Q60838	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Prkcg	Mus musculus	P63318	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	Vang	Drosophila melanogaster	O45030	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	dsh	Drosophila melanogaster	P51140	Anti Tag CoIP	21718540
Intra	Dact3	Q0PHV7	dco	Drosophila melanogaster	O76324	Anti Bait CoIP	21718540

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03517	DACT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dact3	NCBI	NCBI:147906