Dact2 - dishevelled-binding antagonist of beta-catenin 2 Gene

Also Known as Dpr2; Frd2; dapper2; A630024E20; 2900084M21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 240025

Summary

Enables several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and umbilical vein. Orthologous to human DACT2 (dishevelled binding antagonist of beta catenin 2). [provided by Alliance of Genome Resources, Apr 2022]

Dact2 Products (1)

mRNA	Protein	Name
NM_172826.3	NP_766414.3	dapper homolog 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables delta-catenin binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21718540	MGI
enables protein kinase A binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables protein kinase C binding	IDA IDA: Inferred from direct assay	21718540	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	21718540	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	20685821	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	24029230	MGI
involved in inner medullary collecting duct development	IMP IMP: Inferred from mutant phenotype	20685821	MGI
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	18716284	MGI
involved in negative regulation of nodal signaling pathway	IDA IDA: Inferred from direct assay	17197390	MGI
involved in negative regulation of nodal signaling pathway	IMP IMP: Inferred from mutant phenotype	18716284	MGI
NOT involved in regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	17197390	MGI
involved in skin development	IMP IMP: Inferred from mutant phenotype	18716284	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dapper homolog 2	dapper antagonist of catenin 2 dapper homolog 2, antagonist of beta-catenin dapper, antagonist of beta-catenin, homolog 2 mDpr2

Dact2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dact2	Q7TN08	Dact3	Mus musculus	Q0PHV7	Anti Tag CoIP	21718540

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03516	DACT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dact2	NCBI	NCBI:168002