DACT2 - dishevelled binding antagonist of beta catenin 2 Gene

Also Known as DPR2; DAPPER2; C6orf116; bA503C24.7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 168002

About DACT2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:168,292,830-168,319,777 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 2 paralogues. Biased expression in placenta (RPKM 6.6), prostate (RPKM 2.5) and 8 other tissues.

Summary

Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DACT2 Products (3)

mRNA Protein Name
NM_001286350.2 NP_001273279.1 dapper homolog 2 isoform b
NM_001286351.2 NP_001273280.1 dapper homolog 2 isoform c
NM_214462.5 NP_999627.2 dapper homolog 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DACT2 Protein Structure

Dapper

Dapper: Dapper (20 - 774)

  • 0
  • 200
  • 400
  • 600
  • 774 a.a.
Protein Preferred Names Protein Names

dapper homolog 2

  • dapper antagonist of catenin 2

Related Diseases

Diseases Alias
Extraocular Retinoblastoma

  • Pediatric Extraocular Retinoblastoma
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03516 DACT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DACT2 RGD RGD:1310742
Macaca mulatta DACT2 VGNC VGNC:71688
Bos taurus DACT2 VGNC VGNC:27868
Mus musculus DACT2 MGD MGI:1920347
Canis familiaris DACT2 VGNC VGNC:39762