Grin2b - glutamate ionotropic receptor NMDA type subunit 2B Gene

Enables several functions, including beta-catenin binding activity; extracellular ligand-gated monoatomic ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ketone; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Used to study attention deficit hyperactivity disorder; cannabis abuse; fetal alcohol spectrum disorder; hyperhomocysteinemia; and transient cerebral ischemia. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; cognitive disorder (multiple); drug dependence (multiple); and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; Neurodegenerative Disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Jun 2026]
Restricted expression toward (RPKM 321.7).