Patj - PATJ, crumbs cell polarity complex component Gene

Also Known as Cipp; Inadl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12695

Summary

This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Patj Products (5)

mRNA Protein Name
NM_001005784.1 NP_001005784.1 inaD-like protein isoform 2
NM_001005787.1 NP_001005787.1 inaD-like protein isoform 4
NM_001355177.1 NP_001342106.1 inaD-like protein isoform 5
NM_007704.2 NP_031730.1 inaD-like protein isoform 3
NM_172696.2 NP_766284.2 inaD-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9647694 MGI
Cellular Component GO Annotation Evidence References Source
is active in apical part of cell IDA
IDA: Inferred from direct assay
25636444 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
14758363 MGI
part of subapical complex IDA
IDA: Inferred from direct assay
16885194 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inaD-like protein

  • PALS1-associated tight junction protein

  • channel-interacting PDZ domain protein

  • channel-interacting PDZ domain-containing protein

  • inactivation no after-potential D-like protein

  • novel ankyrin-repeat protein

  • protein associated to tight junctions

Patj Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Patj Q63ZW7 Grin2a Mus musculus P35436
Pull Down
9647694
Cross
Patj Q63ZW7 KCNJ15 Homo sapiens Q99712
Pull Down
9647694
Cross
Patj Q63ZW7 KCNJ15 Homo sapiens Q99712
Y2H
9647694
Cross
Patj Q63ZW7 Grin2b Rattus norvegicus Q00960
Pull Down
9647694
Cross
Patj Q63ZW7 Grin2b Rattus norvegicus Q00960
Y2H
9647694
Cross
Patj Q63ZW7 Grin2c Rattus norvegicus Q00961
Y2H
9647694
Cross
Patj Q63ZW7 Grin2c Rattus norvegicus Q00961
Pull Down
9647694
Cross
Patj Q63ZW7 Grin2d Rattus norvegicus Q62645
Pull Down
9647694
Cross
Patj Q63ZW7 Grin2d Rattus norvegicus Q62645
Y2H
9647694
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10083 PATJ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Patj NCBI NCBI:10207