KCNJ15 - potassium inwardly rectifying channel subfamily J member 15 Gene

Also Known as IRKK; KIR1.3; KIR4.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3772

About KCNJ15

Cytogenetic location: 21q22.13-q22.2 Genomic coordinates (GRCh38): 21:38,229,926-38,307,357 (from NCBI)

This gene has 22 transcripts (splice variants), 198 orthologues and 15 paralogues. Biased expression in kidney (RPKM 38.5), thyroid (RPKM 23.6) and 6 other tissues.

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

KCNJ15 Products (8)

mRNA Protein Name
NM_001276435.2 NP_001263364.1 ATP-sensitive inward rectifier potassium channel 15
NM_001276436.2 NP_001263365.1 ATP-sensitive inward rectifier potassium channel 15
NM_001276437.2 NP_001263366.1 ATP-sensitive inward rectifier potassium channel 15
NM_001276438.2 NP_001263367.1 ATP-sensitive inward rectifier potassium channel 15
NM_001276439.2 NP_001263368.1 ATP-sensitive inward rectifier potassium channel 15
NM_002243.5 NP_002234.2 ATP-sensitive inward rectifier potassium channel 15
NM_170736.3 NP_733932.1 ATP-sensitive inward rectifier potassium channel 15
NM_170737.3 NP_733933.1 ATP-sensitive inward rectifier potassium channel 15

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9647694 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNJ15 Protein Structure

IRK

IRK: Inward rectifier potassium channel (30 - 364)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 15

  • inward rectifier K(+) channel Kir1.3

KCNJ15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
KCNJ15 Q99712 Patj Mus musculus Q63ZW7
Y2H
9647694
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vitreoretinal Degeneration, Snowflake Type

  • Snowflake Vitreoretinal Degeneration

  • SVD

  • Snowflake Degeneration In Hereditary Vitreoretinal Degeneration
Hypomagnesemia 4, Renal

  • Renal Hypomagnesemia 4

  • HOMG4

  • Hypomagnesemia, Renal, Normocalciuric

  • Hypomagnesemia 4

  • Renal Hypomagnesemia Normocalciuric

  • Hypomagnesemia, Type 4, Renal
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance

  • Sesame Syndrome

  • East Syndrome

  • SESAMES

  • Epilepsy, Ataxia, Sensorineural Deafness And Tubulopathy

  • Seizures, Sensorineural Deafness, Ataxia, Mental Retardation And Electrolyte Imbalance

  • Epilepsy-Ataxia-Sensorineural Deafness-Tubulopathy Syndrome

  • Seizures-Sensorineural Deafness-Ataxia-Intellectual Disability-Electrolyte Imbalance Syndrome

  • Epilepsy, Ataxia, Sensorineural Deafness, And Tubulopathy

  • Seizures - Sensorineural Deafness - Ataxia - Intellectual Disability - Electrolyte Imbalance

  • Epilepsy-Ataxia-Sensorineural Hearing Loss-Tubulopathy Syndrome

  • Seizures-Sensorineural Hearing Loss-Ataxia-Intellectual Disability-Electrolyte Imbalance Syndrome

  • Seizures, Sensorineural Deafness, Ataxia, Intellectual Disability, And Electrolyte Imbalance

  • Epilepsy Ataxia Sensorineural Deafness And Tubulopathy

  • Seizures, Sensorineural Deafness, Ataxia, Intellectual Disability, And Electrolyte Imbalance Syndrome
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07142 KCNJ15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KCNJ15 VGNC VGNC:67913
Macaca mulatta KCNJ15 VGNC VGNC:73986
Mus musculus KCNJ15 MGD MGI:1310000
Bos taurus KCNJ15 VGNC VGNC:30458
Rattus norvegicus KCNJ15 RGD RGD:621662
Canis familiaris KCNJ15 VGNC VGNC:42261
Others KCNJ15 NCBI