Dlg3 - discs large MAGUK scaffold protein 3 Gene

Also Known as Dlgh3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58948

Summary

Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and protein C-terminus binding activity. A structural constituent of postsynaptic density. Involved in positive regulation of protein tyrosine kinase activity. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Dlg3 Products (1)

mRNA Protein Name
NM_031639.2 NP_113827.1 disks large homolog 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15024025 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
16540568 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8702950 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
9115257 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
20410104 RGD
enables structural constituent of postsynaptic density IDA
IDA: Inferred from direct assay
20357126 RGD
enables structural constituent of postsynaptic density IMP
IMP: Inferred from mutant phenotype
20357126 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic shaft IDA
IDA: Inferred from direct assay
12738960 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20357126 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20357126 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12738960 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12738960 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
12738960 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
20357126 RGD
located in synapse IDA
IDA: Inferred from direct assay
12738960 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 3

  • PSD-95/SAP90-related protein 1

  • SAP-102

  • SAP102

  • discs, large homolog 3

  • synapse-associated protein 102

Dlg3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Dlg3 Q62936 GRIN2D Homo sapiens O15399
ELISA
11937501
Cross
Dlg3 Q62936 GRIN2B Homo sapiens Q13224
ELISA
11937501
Cross
Dlg3 Q62936 GRIN2B Homo sapiens Q13224
FPS
11937501
Intra
Dlg3 Q62936 Grin2b Rattus norvegicus Q00960
Filter Binding
8780649
Intra
Dlg3 Q62936 Grin2b Rattus norvegicus Q00960
ELISA
8780649
Cross
Dlg3 Q62936 GRIN2A Homo sapiens Q12879
ELISA
11937501
Cross
Dlg3 Q62936 GRIN2C Homo sapiens Q14957
ELISA
11937501
Cross
Dlg3 Q62936 GRIN2C Homo sapiens Q14957
FPS
11937501
Cross
Dlg3 Q62936 GRIN1 Homo sapiens Q05586-2
FPS
11937501
Cross
Dlg3 Q62936 KCNA1 Homo sapiens Q09470
ELISA
11937501
Intra
Dlg3 Q62936 Dgkz Rattus norvegicus O08560
Y2H
19229292
Intra
Dlg3 Q62936 Lrfn2 Rattus norvegicus Q460M5
Anti Bait CoIP
16495444
Cross
Dlg3 Q62936 CRIPT Homo sapiens Q9P021
ELISA
11937501
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03798 DLG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08624 MPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20714 Dlg3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27225 Dlg3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlg3 NCBI NCBI:1741