GRIN2B - glutamate ionotropic receptor NMDA type subunit 2B Gene

Also Known as NR3; MRD6; NR2B; hNR3; DEE27; EIEE27; GluN2B; NMDAR2B

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 2904

Summary

This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA Receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017]

GRIN2B Products (1)

mRNA Protein Name
XM_054371855.1 XP_054227830.1 glutamate receptor ionotropic, NMDA 2B isoform X2
Protein Preferred Names Protein Names

glutamate receptor ionotropic, NMDA 2B

  • GluN2B(alt_5'UTR)

  • N-methyl D-aspartate receptor subtype 2B

  • N-methyl-D-aspartate receptor subunit 3

  • glutamate [NMDA] receptor subunit epsilon-2

  • glutamate receptor subunit epsilon-2

  • glutamate receptor, ionotropic, N-methyl D-aspartate 2B

GRIN2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRIN2B Q13224 CAMK2A Homo sapiens Q9UQM7
Fluorescence
19453375
Intra
GRIN2B Q13224 DLG1 Homo sapiens Q12959
Phage Display
24550280
Intra
GRIN2B Q13224 DLG1 Homo sapiens Q12959
Y2H
35914814
Cross
GRIN2B Q13224 PPP1CA Oryctolagus cuniculus P62139
Phosphatase Assay
19453375
Cross
GRIN2B Q13224 PPP1CA Oryctolagus cuniculus P62139
Phenotype-Based
19453375
Cross
GRIN2B Q13224 Dlg3 Rattus norvegicus Q62936
ELISA
11937501
Cross
GRIN2B Q13224 Dlg4 Rattus norvegicus P31016
ELISA
11937501
Cross: Cross-species interaction Intra: Intraspecies interaction

GRIN2B Antibodies

Cat. No. Product Name Application Reactivity
HY-P84531 GRIN2B Antibody (YA4228) ICC/IF, FC, ELISA Human
HY-P84531A GRIN2B Antibody (YA4228)(PBS only) ICC/IF, FC, ELISA Human