Gria1 - glutamate ionotropic receptor AMPA type subunit 1 Gene

Also Known as GluA1; gluR-A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50592

Summary

Enables several functions, including AMPA glutamate receptor activity; enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organonitrogen compound; long-term memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Used to study hyperhomocysteinemia. Biomarker of epilepsy; hepatic encephalopathy; status epilepticus; and visual epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Gria1 Products (1)

mRNA Protein Name
NM_031608.2 NP_113796.1 glutamate receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables AMPA glutamate receptor activity IDA
IDA: Inferred from direct assay
19265014 RGD
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
19942860 RGD
enables G-protein beta-subunit binding IDA
IDA: Inferred from direct assay
19942860 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
16634638 RGD
enables adenylate cyclase binding IDA
IDA: Inferred from direct assay
19942860 RGD
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
20032460 RGD
enables beta-2 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
19942860 RGD
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
21639859 RGD
enables glutamate-gated calcium ion channel activity IDA
IDA: Inferred from direct assay
1709304 RGD
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
1699275 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19461580 RGD
enables immunoglobulin binding IPI
IPI: Inferred from physical interaction
26595655 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
10414981 RGD
enables myosin V binding IPI
IPI: Inferred from physical interaction
16338934 RGD
enables peptide hormone receptor binding IPI
IPI: Inferred from physical interaction
25539504 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9677374 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17194442 RGD
enables protein kinase A binding IDA
IDA: Inferred from direct assay
19942860 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17329210 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
10939335 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
17194442 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
10731148 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
10731148 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to pain IEP
IEP: Inferred from expression pattern
25716866 RGD
involved in cellular response to L-glutamate IEP
IEP: Inferred from expression pattern
12390532 RGD
involved in cellular response to amine stimulus IEP
IEP: Inferred from expression pattern
19674091 RGD
involved in cellular response to amino acid stimulus IEP
IEP: Inferred from expression pattern
19913087 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IDA
IDA: Inferred from direct assay
14597197 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
24712995 RGD
involved in cellular response to dsRNA IEP
IEP: Inferred from expression pattern
19958814 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
19958814 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20025928 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
20237279 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
14597197 RGD
involved in conditioned place preference IMP
IMP: Inferred from mutant phenotype
23345231 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
19547753 RGD
involved in long-term synaptic potentiation IEP
IEP: Inferred from expression pattern
26088419 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
11348590 RGD
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
12536214 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
23345231 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23460828 RGD
involved in positive regulation of locomotion involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
21613507 RGD
involved in positive regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
20165912 RGD
involved in positive regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
11348590 RGD
involved in receptor internalization IDA
IDA: Inferred from direct assay
11100149 RGD
involved in regulation of monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
21613507 RGD
involved in regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
11348590 RGD
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
12536214 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
19761793 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
15548228 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
20554014 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19596275 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
21041654 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
19591855 RGD
involved in response to lithium ion IEP
IEP: Inferred from expression pattern
15269270 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
24201449 RGD
involved in response to morphine IMP
IMP: Inferred from mutant phenotype
22072679 RGD
involved in response to nutrient levels IDA
IDA: Inferred from direct assay
21425350 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19940171 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
20554878 RGD
involved in response to psychosocial stress IEP
IEP: Inferred from expression pattern
32594591 RGD
involved in response to sucrose IDA
IDA: Inferred from direct assay
21425350 RGD
involved in response to toxic substance IMP
IMP: Inferred from mutant phenotype
20165912 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19940171 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
19446017 RGD
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
19265014 RGD
located in asymmetric synapse IDA
IDA: Inferred from direct assay
12077196 RGD
located in cell surface IDA
IDA: Inferred from direct assay
19321442 RGD
located in cell-cell junction IDA
IDA: Inferred from direct assay
26595655 RGD
located in cytosol IDA
IDA: Inferred from direct assay
34742997 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12629171 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
11931740 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
11100149 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
12077196 RGD
located in early endosome IDA
IDA: Inferred from direct assay
11100149 RGD
located in early endosome membrane IDA
IDA: Inferred from direct assay
15456832 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
15456832 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
19730411 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12390532 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10731148 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
10731148 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
19918122 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
12390532 RGD
located in neuron spine IDA
IDA: Inferred from direct assay
10985351 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11100149 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
10985351 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
27881773 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
19077125 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
15610164 RGD
located in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
26088419 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
16903873 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
15610164 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
16903873 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17329210 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
23844251 RGD
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
15456832 RGD
located in synapse IDA
IDA: Inferred from direct assay
10939335 RGD
located in synapse IMP
IMP: Inferred from mutant phenotype
12536214 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
10414981 RGD
located in synaptic membrane IMP
IMP: Inferred from mutant phenotype
27307232 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor 1

  • AMPA-selective glutamate receptor 1

  • GluR1

  • gluR-1

  • gluR-K1

  • glutamate receptor A

  • glutamate receptor subunit GluR1

  • glutamate receptor, ionotropic, AMPA 1

  • glutamate receptor, ionotropic, AMPA1 (alpha 1)

Gria1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gria1 P19490 Arhgef2 Rattus norvegicus Q5FVC2
Anti Bait CoIP
19208802
Intra
Gria1 P19490 Cnih2 Rattus norvegicus Q5BJU5
Anti Tag CoIP
20805473
Intra
Gria1 P19490 Cnih2 Rattus norvegicus Q5BJU5
Anti Bait CoIP
20805473
Intra
Gria1 P19490 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
19942860
Intra
Gria1 P19490 Gria2 Rattus norvegicus P19491
Anti Bait CoIP
16338934
Intra
Gria1 P19490 Gria2 Rattus norvegicus P19491
Anti Bait CoIP
19942860
Intra
Gria1 P19490 Cacng2 Rattus norvegicus Q71RJ2
Anti Bait CoIP
20805473
Intra
Gria1 P19490 Cacng2 Rattus norvegicus Q71RJ2
Anti Bait CoIP
19208802
Intra
Gria1 P19490 Gria2 Rattus norvegicus P19491
Solution Sedimentation
21317873
Intra
Gria1 P19490 Dlg4 Rattus norvegicus P31016
Competition Binding
19942860
Intra
Gria1 P19490 Cacng2 Rattus norvegicus Q71RJ2
Anti Tag CoIP
20805473
Intra
Gria1 P19490 Gria1 Rattus norvegicus P19490
Solution Sedimentation
21317873
Intra
Gria1 P19490 Cacng2 Rattus norvegicus Q71RJ2
Anti Tag CoIP
21376300
Intra
Gria1 P19490 Gria1 Rattus norvegicus P19490
Solution Sedimentation
19461580
Intra
Gria1 P19490 Adrb2 Rattus norvegicus P10608
Anti Bait CoIP
19942860
Intra
Gria1 P19490 Myo5b Rattus norvegicus P70569
Anti Bait CoIP
16338934
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05791 GRIA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gria1 NCBI NCBI:2890