GRIA1 - glutamate ionotropic receptor AMPA type subunit 1 Gene

Also Known as GLUH1; GLUR1; GLURA; GluA1; HBGR1; MRD67; MRT76

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2890

About GRIA1

Cytogenetic location: 5q33.2 Genomic coordinates (GRCh38): 5:153,489,615-153,813,869 (from NCBI)

This gene has 13 transcripts (splice variants), 284 orthologues, 17 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 23.3) and lung (RPKM 3.7).

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GRIA1 Products (10)

mRNA	Protein	Name
NM_000827.4	NP_000818.2	glutamate receptor 1 isoform 1 precursor
NM_001114183.2	NP_001107655.1	glutamate receptor 1 isoform 2 precursor
NM_001258019.2	NP_001244948.1	glutamate receptor 1 isoform 3 precursor
NM_001258020.2	NP_001244949.1	glutamate receptor 1 isoform 4
NM_001258021.2	NP_001244950.1	glutamate receptor 1 isoform 5
NM_001258022.2	NP_001244951.1	glutamate receptor 1 isoform 6
NM_001258023.1	NP_001244952.1	glutamate receptor 1 isoform 7
NM_001364165.2	NP_001351094.1	glutamate receptor 1 isoform 8 precursor
NM_001364166.2	NP_001351095.1	glutamate receptor 1 isoform 9
NM_001364167.2	NP_001351096.1	glutamate receptor 1 isoform 10

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AMPA glutamate receptor activity	IDA IDA: Inferred from direct assay	1311100	GOA
enables AMPA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	28628100	GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	8824304	GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	8824304	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20805473	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	23739980	GOA
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	20434989	GOA
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	23739980	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	20434989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIA1 Protein Structure

ANF_receptor

SBP_bac_3

Lig_chan

0
200
400
600
800
906 a.a.

Protein Preferred Names	Protein Names
glutamate receptor 1	AMPA 1

GRIA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GRIA1	P42261	ASCL4	Homo sapiens	Q6XD76	Y2H Array	32814053
Intra	GRIA1	P42261	ASCL4	Homo sapiens	Q6XD76	Y2H Pooling	32814053
Intra	GRIA1	P42261	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32814053
Intra	GRIA1	P42261	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	GRIA1	P42261	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Intra	GRIA1	P42261	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	GRIA1	P42261	RAB11B	Homo sapiens	Q15907	Y2H Array	32814053
Intra	GRIA1	P42261	RAB11B	Homo sapiens	Q15907	Y2H Pooling	32814053
Intra	GRIA1	P42261	RAB11B	Homo sapiens	Q15907	Validated Y2H	32814053
Intra	GRIA1	P42261	ZNF232	Homo sapiens	Q9UNY5	Y2H Pooling	32814053
Intra	GRIA1	P42261	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32814053
Intra	GRIA1	P42261	ZNF232	Homo sapiens	Q9UNY5	Y2H Array	32814053
Intra	GRIA1	P42261	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053
Intra	GRIA1	P42261	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	GRIA1	P42261	BECN1	Homo sapiens	Q14457	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

GRIA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80407	Glutamate Receptor 1 (AMPA Subtype) Antibody (YA407)	WB, IHC-P, IP	Mouse, Rat
HY-P810593	Phospho-GluR1 (AMPA subtype) (Ser831) Antibody (YA9857)	WB	Human, Mouse, Rat
HY-P810594	Phospho-GluR1 (Ser845) Antibody (YA9858)	WB, FC	Human, Mouse, Rat
HY-P82336	Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)	WB	Human, Rat
HY-P82336A	Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)(PBS only)	WB	Human, Rat
HY-P86115	Glutamate Receptor 1 (AMPA Subtype) Antibody (YA5807)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Recessive 76	MRT76 Mental Retardation, Autosomal Recessive 76 Autosomal Recessive Intellectual Developmental Disorder 76 Intellectual Developmental Disorder, Autosomal Recessive, Type 76
Intellectual Developmental Disorder, Autosomal Dominant 67	MRD67 Mental Retardation, Autosomal Dominant 67 Intellectual Developmental Disorder, Autosomal Dominant, Type 67
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Limbic Encephalitis
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Retrograde Amnesia	Amnesia, Retrograde
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Morphine Dependence
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Flying Phobia	Aerophobia
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Mental Depression	Depression Depressive Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Specific Developmental Disorder
Trombiculiasis
Disease Of Mental Health	Mental Health Mental Disorders
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Syndromic Intellectual Disability
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05791	GRIA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GRIA1	VGNC	VGNC:41480
Rattus norvegicus	GRIA1	RGD	RGD:621531
Felis catus	GRIA1	VGNC	VGNC:67461
Mus musculus	GRIA1	MGD	MGI:95808
Bos taurus	GRIA1	VGNC	VGNC:29638
Macaca mulatta	GRIA1	VGNC	VGNC:73271
Others	GRIA1	NCBI