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Myo5b - myosin Vb Gene

Also Known as Myr6

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25132

Summary

Enables several functions, including ATP hydrolysis activity; ionotropic glutamate receptor binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to glycine; generation of neurons; and positive regulation of exosomal secretion. Located in dendritic spine; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic actin cytoskeleton; and postsynaptic recycling endosome membrane. Colocalizes with recycling endosome. Human ortholog(s) of this gene implicated in microvillus inclusion disease. Orthologous to human MYO5B (Myosin VB). [provided by Alliance of Genome Resources, Apr 2022]

Myo5b Products (1)

mRNA	Protein	Name
NM_017083.2	NP_058779.2	unconventional myosin-Vb

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	18984164	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	16338934	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16338934	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	23770993	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glycine	IEP IEP: Inferred from expression pattern	18984164	RGD
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	18984164	RGD
involved in neurotransmitter receptor transport, endosome to plasma membrane	IDA IDA: Inferred from direct assay	18984164	RGD
involved in neurotransmitter receptor transport, endosome to plasma membrane	IMP IMP: Inferred from mutant phenotype	18984164	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	23770993	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23554492	RGD
involved in positive regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	18984164	RGD
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19542231	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	18984164	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	18984164	RGD
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	18701652	RGD
involved in synaptic vesicle recycling via endosome	IDA IDA: Inferred from direct assay	18984164	RGD
involved in synaptic vesicle recycling via endosome	IMP IMP: Inferred from mutant phenotype	18984164	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	18984164	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	18984164	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18984164	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	18984164	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16338934	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18984164	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18984164	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16338934	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16338934	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	18984164	RGD
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	18984164	RGD
is active in postsynaptic recycling endosome membrane	IDA IDA: Inferred from direct assay	18984164	RGD
is active in postsynaptic recycling endosome membrane	IMP IMP: Inferred from mutant phenotype	18984164	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	18984164	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
unconventional myosin-Vb	Myosin of the dilute-myosin-V family myosin 5B myosin heavy chain myr 6

Myo5b Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Myo5b	P70569	Gria1	Rattus norvegicus	P19490	Anti Bait CoIP	16338934

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08947	MYO5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-D3304	Cholyl-L-lysine fluorescein disodium		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo5b	NCBI	NCBI:4645