Arhgef2 - Rho/Rac guanine nucleotide exchange factor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310635

Summary

Predicted to enable guanyl-nucleotide exchange factor activity; microtubule binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including generation of neurons; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of podosome assembly. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef2 Products (1)

mRNA Protein Name
NM_001012079.2 NP_001012079.1 rho guanine nucleotide exchange factor 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19208802 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19208802 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19208802 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
19208802 RGD
is active in postsynaptic density, intracellular component IMP
IMP: Inferred from mutant phenotype
19208802 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 2

  • GEF-H1

  • guanine nucleotide exchange factor H1

  • rho/rac guanine nucleotide exchange factor (GEF) 2

Arhgef2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Arhgef2 Q5FVC2 Gria1 Rattus norvegicus P19490
Anti Bait CoIP
19208802
Intra
Arhgef2 Q5FVC2 Gria1 Rattus norvegicus P19490
Anti Tag CoIP
19208802
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00954 ARHGEF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgef2 NCBI NCBI:9181