ZP2 - zona pellucida glycoprotein 2 Gene

Also Known as ZPA; Zp-2; OOMD6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7783

About ZP2

Cytogenetic location: 16p12.3-p12.2 Genomic coordinates (GRCh38): 16:21,197,450-21,214,510 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 218 orthologues, 4 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

ZP2 Products (4)

mRNA	Protein	Name
NM_001376231.1	NP_001363160.1	zona pellucida sperm-binding protein 2 isoform 2 preproprotein
NM_001376232.1	NP_001363161.1	zona pellucida sperm-binding protein 2 isoform 1 preproprotein
NM_001376233.1	NP_001363162.1	zona pellucida sperm-binding protein 2 isoform 3 preproprotein
NM_003460.2	NP_003451.1	zona pellucida sperm-binding protein 2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acrosin binding	IPI IPI: Inferred from physical interaction	15950651	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26879157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15950651	GOA
enables structural constituent of egg coat	IMP IMP: Inferred from mutant phenotype	29895852	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in regulation of acrosome reaction	IDA IDA: Inferred from direct assay	11751269	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in egg coat	IDA IDA: Inferred from direct assay	29895852	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZP2 Protein Structure

Zona_pellucida

0
200
400
600
745 a.a.

Protein Preferred Names	Protein Names
zona pellucida sperm-binding protein 2	zona pellucida 2

ZP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZP2	Q05996	VDAC2	Homo sapiens	P45880-3	Pull Down	23355646
Intra	ZP2	Q05996	VDAC2	Homo sapiens	P45880-3	Far-WB	23355646
Intra	ZP2	Q05996	ZP2	Homo sapiens	Q05996	IR Spectrometry	26879157
Intra	ZP2	Q05996	ACR	Homo sapiens	P10323	ELISA	15950651
Intra	ZP2	Q05996	PKM	Homo sapiens	P14618-2	Far-WB	23355646
Intra	ZP2	Q05996	GPX4	Homo sapiens	P36969	Far-WB	23355646
Intra	ZP2	Q05996	ZP2	Homo sapiens	Q05996	EM	26879157
Intra	ZP2	Q05996	ZP2	Homo sapiens	Q05996	X-Ray Diffraction	26879157
Intra	ZP2	Q05996	FAR2	Homo sapiens	Q96K12	Anti Tag CoIP	33961781
Intra	ZP2	Q05996	PLCG1	Homo sapiens	P19174	Peptide Array	17474147
Intra	ZP2	Q05996	P10323-PRO_0000027518	Homo sapiens	P10323-PRO_0000027518	ELISA	15950651
Intra	ZP2	Q05996	ENO1	Homo sapiens	P06733	Far-WB	23355646
Intra	ZP2	Q05996	GAPDHS	Homo sapiens	O14556	Far-WB	23355646

Cross: Cross-species interaction Intra: Intraspecies interaction

ZP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84491	ZP2 Antibody (YA4188)	IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84491A	ZP2 Antibody (YA4188)(PBS only)	IHC-P, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Oocyte Maturation Defect 6	OOMD6
Female Infertility Due To Zona Pellucida Defect
Infertility
Acheiropody	Acheiropodia ACHP Acheiropody, Brazilian Type Horn-Kolb Syndrome Horn Kolb Syndrome Acheiropody Brazilian Type
Syndactyly, Type Iv	Syndactyly Type 4 Polysyndactyly, Haas Type SDTY4 Haas Type Syndactyly Sd4 Polysyndactyly Type Haas Syndactyly 4 Polysyndactyly Haas Type Syndactyly Type Iv
Tibia, Hypoplasia Or Aplasia Of, With Polydactyly	Hypoplastic Or Aplastic Tibia With Polydactyly Absence Of Tibia With Polydactyly Tibial Hemimelia-Polysyndactyly-Triphalangeal Thumb Syndrome THYP Tibial Hemimelia-Polydactyly-Triphalangeal Thumbs With Fibular Dimelia Absent Tibia-Polydactyly Syndrome Werner Mesomelic Syndrome Hypoplastic Tibiae-Postaxial Polydactyly Syndrome Polydactyly With Absent Tibia Werner Mesomelic Spectrum Hypoplasia Or Aplasia Of Tibia With Polydactyly Wms Tibia, Hypoplasia Of, With Polydactyly
Joubert Syndrome 32	JBTS32
Zygodactyly 1	Zd1 Zygodactyly Type 1 Sd1, Weidenreich Type Sd1a Syndactyly Type 1, Weidenreich Type Syndactyly Type 1a Zygodactyly, Weidenreich Type
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Laurin-Sandrow Syndrome	Sandrow Syndrome Tetramelic Mirror-Image Polydactyly Mirror-Image Polydactyly Mirror Hands And Feet With Nasal Defects Tmip LSS Mip Mirror Hands And Feets-Nasal Defects Syndrome Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius Miccor Hands And Feet With Nasal Defects Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius Fibula Ulna Duplication Tibia Radius Absence Laurin Sandrow Syndrome Duplication Of Fibula And Ulna With Absence Of Tibia And Radius Segmental Laurin-Sandrow Syndrome Laurin-Sandrow Syndrome, Segmental
Epilepsy, Idiopathic Generalized 2	EIG2 Epilepsy, Idiopathic Generalized, Susceptibility To, 2 Idiopathic Generalized Epilepsy 2 Epilepsy, Idiopathic Generalized Locus On Chromosome 14 Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 14
Cataract 1, Multiple Types	Cataract 1 Multiple Types CTRCT1 Cataract 1, Multiple Types, With Or Without Microcornea Czp1 Cae1 Pulverulent Zonular Cataract Cataract, Duffy-Linked Cataract, Zonular Pulverulent, 1 Duffy Linked Cataract Zonular Pulverulent Cataract 1 Cataract Duffy-Linked Cataract-Microcornea Syndrome Cataract Zonular Pulverulent 1 Ccmc Cznp Czp Zonular Nuclear Pulverulent Cataract Cataract, Zonular Pulverulent-1 Zonular Pulverulent Cataract Cataract, Zonular Pulverulent 1 Cataract Microcornea Syndrome
Syndactyly, Type Iii	Syndactyly Type 3 SDTY3 Ring And Little Finger Syndactyly Syndactyly Of Fingers Iv And V Syndactyly Of Fingers 4 And 5 Ringand Little Finger Syndactyly Syndactyly Of Fingers Four And Five Syndactyly Of The Ring And Little Finger Sd3 Syndactyly 3 Syndactyly Type Iii 4-5 Finger Syndactyly Syndactyly, Type 3
Greig Cephalopolysyndactyly Syndrome	GCPS Polysyndactyly With Peculiar Skull Shape Polysyndactyly With Peculiars Skull Shape Greig Syndrome Cephalopolysyndactyly Syndrome Greig Cephalo-Poly-Syndactyly Syndrome Cephalopolysyndactyly, Greig Syndrome Aarskog Syndrome
Megalencephalic Leukoencephalopathy With Subcortical Cysts 1	Van Der Knaap Disease Leukoencephalopathy With Swelling And Cysts MLC1 Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts Lvm Vl Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1 Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1 Megalencephalic Leukoencephalopathy With Subcortical Cysts
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Synpolydactyly	Syndactyly Type 2 Syndactyly, Type 2 Spd
Duane-Radial Ray Syndrome	Okihiro Syndrome DRRS Dr Syndrome Duane Anomaly With Radial Ray Abnormalities And Deafness Acrorenoocular Syndrome Acrorenocular Syndrome Duane Anomaly With Radial Abnormalities And Deafness Acro-Renal-Ocular Syndrome
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Synostosis
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Chromosomal Duplication Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16187	ZP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZP2	VGNC	VGNC:78914
Canis familiaris	ZP2	VGNC	VGNC:48842
Rattus norvegicus	ZP2	RGD	RGD:620605
Felis catus	ZP2	VGNC	VGNC:80708
Bos taurus	ZP2	VGNC	VGNC:37366
Mus musculus	ZP2	MGD	MGI:99214
Others	ZP2	NCBI