NDNF - neuron derived neurotrophic factor Gene

Also Known as HH25; NORD; C4orf31

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79625

About NDNF

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:121,035,613-121,072,535 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and is associated with 3 phenotypes. Biased expression in lung (RPKM 64.4), placenta (RPKM 31.0) and 9 other tissues.

Summary

Predicted to enable heparin binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of apoptotic process; and nitric oxide mediated signal transduction. Located in extracellular space. Implicated in hypogonadotropic hypogonadism. [provided by Alliance of Genome Resources, Apr 2022]

NDNF Products (1)

mRNA Protein Name
NM_024574.4 NP_078850.3 protein NDNF precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
24706764 GOA
involved in cellular response to fibroblast growth factor stimulus IMP
IMP: Inferred from mutant phenotype
31883645 GOA
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
24706764 GOA
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
24706764 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
20969804 GOA
involved in neuron migration IDA
IDA: Inferred from direct assay
20969804 GOA
involved in nitric oxide mediated signal transduction IDA
IDA: Inferred from direct assay
24706764 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
20969804 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
20969804 GOA
is active in extracellular space IDA
IDA: Inferred from direct assay
35037619 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
31883645 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDNF Protein Structure

DUF2369

DUF2369: Uncharacterised conserved protein (DUF2369) (153 - 220)

DUF2369

DUF2369: Uncharacterised conserved protein (DUF2369) (287 - 568)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 568 a.a.
Protein Preferred Names Protein Names

protein NDNF

  • fibronectin type-III domain-containing protein C4orf31

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 25 With Anosmia

  • HH25
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Hypogonadotropic Hypogonadism

  • Klinefelter Syndrome

  • Klinefelter'S Syndrome

  • Xxy Syndrome

  • Xxy Trisomy

  • Hypogonadotropism

  • 47, Xxy

  • Congenital Idiopathic Hypogonadotropic Hypogonadism

  • Isolated Congenital Gonadotropin Deficiency

  • 47,Xxy Syndrome

  • 47, Xxy Syndrome

  • Klinefelters Syndrome

  • Hypogonadism

  • Klinefelter Syndrome In Males

  • Klinefelter Syndrome, Unspecified

  • Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Arthrogryposis, Distal, Type 1b

  • DA1B

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1b
Arthrogryposis, Distal, Type 1a

  • Distal Arthrogryposis Type 1

  • Digitotalar Dysmorphism

  • DA1A

  • Da1

  • Amcd1

  • Arthrogryposis, Distal, Type 2b4

  • Distal Arthrogryposis Type 1a

  • Arthrogryposis, Distal, Type 1

  • Arthrogryposis Multiplex Congenita Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal, Type I

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1a

  • Amc

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis, Distal, 2b4

  • DA2B4

  • Arthrogryposis Multiplex Congenita, Distal, Type 1

  • Arthrogryposis
Retinitis Pigmentosa 19

  • RP19

  • Retinitis Pigmentosa-19

  • Retinitis Pigmentosa, Type 19
Sensorineural Hearing Loss

  • Sensory Hearing Loss

  • Sensorineural Deafness

  • Sensorineural Hearing Loss Disorder

  • Hearing Loss, Sensorineural

  • Central Hearing Loss

  • High Frequency Deafness

  • High Frequency Hearing Loss

  • High-Frequency Hearing Loss

  • Perceptive Deafness

  • Perceptive Hearing Loss

  • Perceptive Hearing Loss Or Deafness

  • Hearing Loss Sensorineural

  • Deafness Sensorineural

  • Hearing Loss High-Frequency

  • Hearing Loss, Central

  • Hearing Loss, High-Frequency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09111 NDNF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NDNF VGNC VGNC:31937
Mus musculus NDNF MGD MGI:1915419
Macaca mulatta NDNF VGNC VGNC:75027
Canis familiaris NDNF VGNC VGNC:43676
Felis catus NDNF VGNC VGNC:63752
Rattus norvegicus NDNF RGD RGD:1311080
Others NDNF NCBI