RPL14 - ribosomal protein L14 Gene

Also Known as L14; RL14; hRL14; CTG-B33; CAG-ISL-7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9045

About RPL14

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:40,457,339-40,468,587 (from NCBI)

This gene has 9 transcripts (splice variants) and 242 orthologues. Ubiquitous expression in ovary (RPKM 576.2), lymph node (RPKM 328.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL14 Products (2)

mRNA Protein Name
NM_001034996.3 NP_001030168.1 60S ribosomal protein L14
NM_003973.5 NP_003964.3 60S ribosomal protein L14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11369516 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
enables structural constituent of ribosome IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Biological Process GO Annotation Evidence References Source
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
18697920 GOA
involved in ribosomal large subunit biogenesis IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Cellular Component GO Annotation Evidence References Source
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
32669547 GOA
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
25901680 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
is active in postsynaptic density EXP
EXP: Inferred from Experiment
21170055 GOA
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21170055 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL14 Protein Structure

Ribosomal_L14e

Ribosomal_L14e: Ribosomal protein L14 (47 - 122)

  • 0
  • 100
  • 200
  • 215 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L14

  • large ribosomal subunit protein eL14

RPL14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPL14 P50914 RPL4 Homo sapiens P36578
Anti Tag CoIP
33961781
Intra
RPL14 P50914 RPL4 Homo sapiens P36578
Anti Tag CoIP
28514442
Intra
RPL14 P50914 H1-4 Homo sapiens P10412
Anti Tag CoIP
33961781
Intra
RPL14 P50914 H1-4 Homo sapiens P10412
Crosslink
30021884
Intra
RPL14 P50914 PHLDA1 Homo sapiens Q8WV24
Pull Down
11369516
Intra
RPL14 P50914 PHLDA1 Homo sapiens Q8WV24
Y2H
11369516
Cross: Cross-species interaction Intra: Intraspecies interaction

RPL14 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810263 Ribosomal Protein L14 Antibody (YA9607) ICC/IF, IF-Tissue, IHC-P, ELISA human
HY-P811252 RPL14 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 15

  • Hypertrophic Cardiomyopathy 15

  • CMH15

  • Cardiomyopathy, Hypertrophic, 15

  • Cardiomyopathy Familial Hypertrophic 15

  • Cardiomyopathy, Familial Hypertrophic 15

  • Cardiomyopathy, Hypertrophic, Familial, Type 15
Cardiac Valvular Dysplasia, X-Linked

  • Xmvd

  • X-Linked Cardiac Valvular Dysplasia

  • CVD1

  • Filamin A-Related X-Linked Myxomatous Valvular Dysplasia

  • Flna-Related Valvular Dystrophy

  • Flna-Related X-Linked Myxomatous Valvular Dysplasia

  • Valvular Heart Disease, Congenital

  • Myxomatous Valvular Dystrophy, X-Linked

  • Congenital Valvular Heart Disease

  • X-Linked Myxomatous Valvular Dystrophy

  • CVDPX

  • Ehlers-Danlos Syndrome, Type V, Formerly

  • Eds5, Formerly

  • Dystrophie Valvulaire Associee A Flna

  • Eds 5

  • Ehlers-Danlos Syndrome, Type 5

  • Dystrophie Valvulaire Associée À Flna

  • Filamin-A-Associated Myxomatous Mitral Valve Disease

  • Filamin-A-Related Myxomatous Mitral Valve Dystrophy

  • Congenital Valvular Dysplasia

  • Cvdx

  • Ehlers-Danlos Syndrome Type 5
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12166 RPL14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RPL14 VGNC VGNC:34110
Mus musculus RPL14 MGD MGI:1914365
Rattus norvegicus RPL14 RGD RGD:621180
Others RPL14 NCBI