H1-4 - H1.4 linker histone, cluster member Gene

Also Known as H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3008

About H1-4

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,156,329-26,157,115 (from NCBI)

This gene has 1 transcript (splice variant), 128 orthologues, 9 paralogues and is associated with 2 phenotypes.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-4 Products (1)

mRNA Protein Name
NM_005321.3 NP_005312.1 histone H1.4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IMP
IMP: Inferred from mutant phenotype
15911621 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
15469825 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
Cellular Component GO Annotation Evidence References Source
located in heterochromatin IDA
IDA: Inferred from direct assay
15911621 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17540172 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-4 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (38 - 109)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

histone H1.4

  • H1 histone family, member 4

H1-4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H1-4 P10412 H2BC21 Homo sapiens Q16778
Crosslink
30021884
Intra
H1-4 P10412 L3MBTL1 Homo sapiens Q9Y468
Pull Down
17540172
Cross
H1-4 P10412 N SARS-CoV-2 P0DTC9
Anti Tag CoIP
36217030
Intra
H1-4 P10412 UTP3 Homo sapiens Q9NQZ2
Anti Tag CoIP
33961781
Intra
H1-4 P10412 FTSJ3 Homo sapiens Q8IY81
Anti Tag CoIP
33961781
Intra
H1-4 P10412 FTSJ3 Homo sapiens Q8IY81
Anti Tag CoIP
28514442
Intra
H1-4 P10412 BAZ1B Homo sapiens Q9UIG0
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

H1-4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83261 Histone H1.3 Antibody (YA3006) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P83261A Histone H1.3 Antibody (YA3006)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Rahman Syndrome

  • RMNS
Hist1h1e Syndrome

  • Rahman Syndrome
Plasma Cell Neoplasm

  • Plasma Cell Dyscrasia

  • Paraproteinemias

  • Plasma Cell Tumour

  • Plasmacytic Tumor

  • Multiple Myeloma

  • Plasmacytoma

  • Plasma Cell Tumours

  • Plasma Cells Dyscrasia
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Mcd Diffuse Large B-Cell Lymphoma

  • Mcd Dlbcl

  • Doid:0081066
Weaver Syndrome

  • Wss

  • Weaver-Smith Syndrome

  • WVS

  • Weaver-Like Syndrome

  • Weaver-Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies Syndrome

  • Camptodactyly - Overgrowth - Unusual Facies

  • Ezh2 Related Overgrowth

  • Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

  • Weaver Smith Syndrome

  • Weaver Like Syndrome

  • Weaver Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies

  • Weaver Syndrome 1

  • Weaver Syndrome 2

  • Wvs1

  • Wvs2
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10587 BIX-01294 98.44% Unkown
HY-108239 BIX-01294 trihydrochloride 99.68% Unkown
HY-W013775S N-Desmethyl ofloxacin-d8 / Unkown
HY-E71431 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase / Unkown
HY-RS05949 H1-4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W124387 2,3,13,14-Tetrabromo-6,7,9,10,17,18-hexahydrodibenzo[b,h][1,4,7,10,13]penta / Unkown
HY-W129041 6,7,9,10,17,18-Hexahydrodibenzo[b,h][1,4,7,10,13]pentaoxacyclopentadecin / Unkown
HY-184369 Fluoprazolam / Unkown
HY-69188S 3,4-Dihydro-2H-benzo[b][1,4]thiazine-d2 / Unkown
HY-N1682 2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one / Unkown
HY-W781963 7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one Control / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus H1-4 VGNC VGNC:109858
Bos taurus H1-4 VGNC VGNC:83559
Macaca mulatta H1-4 VGNC VGNC:109744
Mus musculus H1-4 MGD MGI:1931527
Canis familiaris H1-4 VGNC VGNC:83756
Rattus norvegicus H1-4 RGD RGD:2776
Others H1-4 NCBI