L3MBTL1 - L3MBTL histone methyl-lysine binding protein 1 Gene

Homo sapiens

Also known as L3MBTL; ZC2HC3; H-L(3)MBT; dJ138B7.3

Gene ID: 26013 | Gene type: protein coding

About L3MBTL1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,507,697-43,550,954 (from NCBI)

This gene has 33 transcripts (splice variants), 209 orthologues and 18 paralogues. Broad expression in testis (RPKM 4.3), brain (RPKM 2.6) and 23 other tissues.

Summary

This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

L3MBTL1 Products(9)

mRNA	Protein	Name
NM_001377303.1	NP_001364232.1	lethal(3)malignant brain tumor-like protein 1 isoform 3
NM_001377306.1	NP_001364235.1	lethal(3)malignant brain tumor-like protein 1 isoform 4
NM_001377307.1	NP_001364236.1	lethal(3)malignant brain tumor-like protein 1 isoform 5
NM_001377308.1	NP_001364237.1	lethal(3)malignant brain tumor-like protein 1 isoform 6
NM_001377309.1	NP_001364238.1	lethal(3)malignant brain tumor-like protein 1 isoform 7
NM_001377310.1	NP_001364239.1	lethal(3)malignant brain tumor-like protein 1 isoform 8
NM_001377311.1	NP_001364240.1	lethal(3)malignant brain tumor-like protein 1 isoform 9
NM_015478.7	NP_056293.4	lethal(3)malignant brain tumor-like protein 1 isoform 1
NM_032107.5	NP_115479.4	lethal(3)malignant brain tumor-like protein 1 isoform 2

L3MBTL1 Protein Structure

MBT

zf-C2HC

0
200
400
600
840 a.a.

Protein Preferred Names

Protein Names

lethal(3)malignant brain tumor-like protein 1

L3MBTL1, histone methyl-lysine binding protein

Related Diseases

Diseases

Alias

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Bardet-Biedl Syndrome 2

BBS2	Bardet-Biedl Syndrome
Bardet-Biedl Syndrome, Type 2	Bbs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15839	UNC 669	Inhibitor	99.88%	Unkown
HY-16510	UNC926	Inhibitor	99.82%	Unkown
HY-16510A	UNC926 hydrochloride	Inhibitor	/	Unkown
HY-RS07484	L3MBTL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	L3MBTL1	MGD	MGI:2676663
Canis familiaris	L3MBTL1	VGNC	VGNC:54652
Rattus norvegicus	L3MBTL1	RGD	RGD:1307316

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