1. Epigenetics
  2. Epigenetic Reader Domain
  3. UNC 669

UNC 669 

Cat. No.: HY-15839 Purity: 98.57%
Handling Instructions

UNC 669, a ligand for a methyl-lysine binding domain, is a potent L3MBTL1 (IC50=4.2 uM) and L3MBTL3 (3.1 uM) inhibitor.

For research use only. We do not sell to patients.

UNC 669 Chemical Structure

UNC 669 Chemical Structure

CAS No. : 1314241-44-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 135 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
500 mg USD 990 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

UNC 669, a ligand for a methyl-lysine binding domain, is a potent L3MBTL1 (IC50=4.2 uM) and L3MBTL3 (3.1 uM) inhibitor[1].

IC50 & Target

IC50: 4.2 uM/3.1 uM (L3MBTL1/L3MBTL3)[1]

In Vitro

L3MBTL1, a paralogue of Drosophila tumor suppressor lethal(3)malignant brain tumor (l(3)mbt), binds histones in a methylation state-dependent manner and contributes to higher order chromatin structure and transcriptional repression. Similar to L3MBTL1, the closely related protein, L3MBTL3, also contains three MBT repeats and has been shown to play a role in meduloblastoma formation and normal hematopoiesis in humans[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

338.24

Formula

C₁₅H₂₀BrN₃O

CAS No.

1314241-44-5

SMILES

O=C(C1=CC(Br)=CN=C1)N2CCC(N3CCCC3)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (147.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9565 mL 14.7824 mL 29.5648 mL
5 mM 0.5913 mL 2.9565 mL 5.9130 mL
10 mM 0.2956 mL 1.4782 mL 2.9565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

UNC 669UNC669UNC-669Epigenetic Reader DomainL3MBTL1L3MBTL3transcriptionalrepressionMBTrepeatsInhibitorinhibitorinhibit

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Product Name:
UNC 669
Cat. No.:
HY-15839
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