1. Epigenetics
  2. Epigenetic Reader Domain
  3. UNC926 hydrochloride

UNC926 hydrochloride 

Cat. No.: HY-16510A
Handling Instructions

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM.

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UNC926 hydrochloride Chemical Structure

UNC926 hydrochloride Chemical Structure

CAS No. : 1782573-49-2

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Description

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1].

IC50 & Target

IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1]

In Vitro

UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1].
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1].

Molecular Weight

373.72

Formula

C₁₆H₂₂BrClN₂O

CAS No.

1782573-49-2

SMILES

O=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UNC926UNC 926UNC-926Epigenetic Reader DomainL3MBTL1methyl-lysineL3MBTL3H4K20me13xMBTInhibitorinhibitorinhibit

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UNC926 hydrochloride
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HY-16510A
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