1. Epigenetics
  2. Epigenetic Reader Domain
  3. UNC926 hydrochloride

UNC926 hydrochloride 

Cat. No.: HY-16510A
Handling Instructions

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM.

For research use only. We do not sell to patients.

UNC926 hydrochloride Chemical Structure

UNC926 hydrochloride Chemical Structure

CAS No. : 1782573-49-2

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UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1].

IC50 & Target

IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1]

In Vitro

UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1].
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





Room temperature in continental US; may vary elsewhere.


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UNC926 hydrochloride
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