2101955-00-2
2101955-00-2
Chemical Structure
JAK2 JH2 Tracer
- CAS No.: 2101955-00-2
- Formula:C38H27F2N7O6S
- Molecular Weight:747.73
IUPAC Name: 1-(4-((5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzyl)-3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)-1-methylthiourea
InChIKey: OAJQEPALUDJGLJ-UHFFFAOYSA-N
SMILES: S=C(NC1=CC2=C(C3(C4=C(OC5=C3C=CC(O)=C5)C=C(O)C=C4)OC2=O)C=C1)N(CC6=CC=C(NC7=NN(C(C8=C(F)C=CC=C8F)=O)C(N)=N7)C=C6)C
Biological Activity: JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd value of 0.2 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JAK2 JH2 Tracer | 98.03% | JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd value of 0.2 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Newton AS, et al. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett. 2017 May 17;8(6):614-617. [Content Brief]
- [2]. Ihle JN, Gilliland DG. Jak2: normal function and role in hematopoietic disorders. Curr Opin Genet Dev. 2007 Feb;17(1):8-14. [Content Brief]
Keywords
