Itga1 - integrin subunit alpha 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25118

Summary

Enables Collagen binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; and vasodilation. Located in several cellular components, including acrosomal vesicle; external side of plasma membrane; and perikaryon. Orthologous to human ITGA1 (Integrin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Itga1 Products (1)

mRNA Protein Name
NM_030994.2 NP_112256.1 integrin alpha-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IMP
IMP: Inferred from mutant phenotype
16200076 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21969374 RGD
Biological Process GO Annotation Evidence References Source
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
16200076 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
14564503 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
14991844 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
14991844 RGD
involved in vasodilation IMP
IMP: Inferred from mutant phenotype
18245559 RGD
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
9202984 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
14991844 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
14991844 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-1

  • CD49 antigen-like family member A

  • VLA-1

  • laminin and collagen receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991434 SAN-300 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06945 ITGA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19449 Itga1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25941 Itga1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga1 NCBI NCBI:3672
Mus musculus Itga1 NCBI NCBI:109700