ITGA1 - integrin subunit alpha 1 Gene

Also Known as VLA1; CD49a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3672

About ITGA1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,787,916-52,959,209 (from NCBI)

This gene has 8 transcripts (splice variants), 232 orthologues and 17 paralogues. Broad expression in spleen (RPKM 48.2), placenta (RPKM 40.6) and 19 other tissues.

Summary

This gene encodes the alpha 1 subunit of Integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for Collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in Collagen binding. [provided by RefSeq, Jul 2008]

ITGA1 Products (1)

mRNA Protein Name
NM_181501.2 NP_852478.1 integrin alpha-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables collagen binding involved in cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
24823363 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16754661 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
15592458 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
24823363 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15592458 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
19933311 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
11518510 GOA
part of integrin alpha1-beta1 complex IDA
IDA: Inferred from direct assay
24823363 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA1 Protein Structure

VWA

VWA: von Willebrand factor type A domain (172 - 353)

FG-GAP

FG-GAP: FG-GAP repeat (571 - 606)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (664 - 1041)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1179 a.a.
Protein Preferred Names Protein Names

integrin alpha-1

  • CD49 antigen-like family member A

ITGA1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P84411 ITGA1 Antibody (YA4108) IHC-P, ICC/IF, FC, ELISA Human
HY-P84411A ITGA1 Antibody (YA4108)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Colon Carcinoma In Situ

  • Carcinoma In Situ Of Colon

  • Stage 0 Colonic Carcinoma

  • Stage 0 Carcinoma Of Colon

  • Intraepithelial Neoplasia Of Colon, High Grade

  • Carcinoma In Situ Of Cecum

  • Carcinoma In Situ Of Hepatic Flexure

  • Carcinoma In Situ Of Ileocecal Valve

  • Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Arrhythmogenic Right Ventricular Cardiomyopathy

  • Arrhythmogenic Right Ventricular Dysplasia

  • Arvc

  • Arvd

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

  • Arvc Cardiomyopathy

  • Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

  • Arvd/C

  • Right Ventricular Dysplasia, Arrhythmogenic

  • Ventricular Dysplasia, Right, Arrhythmogenic

  • Cardiomyopathy, Ventricular, Right, Arrhythmogenic

  • Dysplasia, Arrhythmogenic Right Ventricular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P991434 SAN-300 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06945 ITGA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19449 Itga1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25941 Itga1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ITGA1 RGD RGD:2923
Mus musculus ITGA1 MGD MGI:96599
Macaca mulatta ITGA1 VGNC VGNC:73772
Felis catus ITGA1 VGNC VGNC:67836
Canis familiaris ITGA1 VGNC VGNC:42120
Bos taurus ITGA1 VGNC VGNC:30310
Others ITGA1 NCBI