ITGA1 - integrin subunit alpha 1 Gene

Homo sapiens

Also known as VLA1; CD49a

Gene ID: 3672 | Gene type: protein coding

About ITGA1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:52,787,916-52,959,209 (from NCBI)

This gene has 8 transcripts (splice variants), 232 orthologues and 17 paralogues. Broad expression in spleen (RPKM 48.2), placenta (RPKM 40.6) and 19 other tissues.

Summary

This gene encodes the alpha 1 subunit of Integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

ITGA1 Products(1)

mRNA	Protein	Name
NM_181501.2	NP_852478.1	integrin alpha-1 precursor

ITGA1 Protein Structure

VWA

FG-GAP

Integrin_alpha2

0
200
400
600
800
1000
1179 a.a.

Protein Preferred Names

Protein Names

integrin alpha-1

CD49 antigen-like family member A

Related Diseases

Diseases

Alias

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon	Stage 0 Colonic Carcinoma
Stage 0 Carcinoma Of Colon	Intraepithelial Neoplasia Of Colon, High Grade
Carcinoma In Situ Of Cecum	Carcinoma In Situ Of Hepatic Flexure
Carcinoma In Situ Of Ileocecal Valve	Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06945	ITGA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ITGA1	RGD	RGD:2923
Mus musculus	ITGA1	MGD	MGI:96599
Macaca mulatta	ITGA1	VGNC	VGNC:73772
Felis catus	ITGA1	VGNC	VGNC:67836
Canis familiaris	ITGA1	VGNC	VGNC:42120
Bos taurus	ITGA1	VGNC	VGNC:30310
Others	ITGA1	NCBI

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