Itga1 - integrin alpha 1 Gene

Also Known as Vla1; CD49A; E130012M19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109700

Summary

Predicted to enable Collagen binding activity involved in cell-matrix adhesion; protein Phosphatase binding activity; and signaling receptor binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway. Acts upstream of or within cell adhesion; cellular extravasation; and neutrophil chemotaxis. Located in basal part of cell and external side of plasma membrane. Is expressed in blood vessel endothelium; embryo mesenchyme; intestine smooth muscle; and lung. Orthologous to human ITGA1 (Integrin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Itga1 Products (1)

mRNA Protein Name
NM_001033228.3 NP_001028400.2 integrin alpha-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11470831 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
10528208 MGI
acts upstream of or within cellular extravasation IMP
IMP: Inferred from mutant phenotype
10528208 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15592458 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
10528208 MGI
Cellular Component GO Annotation Evidence References Source
located in basal part of cell IDA
IDA: Inferred from direct assay
11767049 MGI
located in cell surface IDA
IDA: Inferred from direct assay
23023225 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9553049 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-1

  • CD49 antigen-like family member A

  • VLA-1

  • laminin and collagen receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991434 SAN-300 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06945 ITGA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19449 Itga1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25941 Itga1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itga1 NCBI NCBI:3672