WLS - Wnt ligand secretion mediator Gene

Also Known as EVI; MRP; ZKS; GPR177; mig-14; C1orf139

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79971

About WLS

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:68,098,459-68,232,546 (from NCBI)

This gene has 14 transcripts (splice variants), 241 orthologues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 32.7), gall bladder (RPKM 31.7) and 24 other tissues.

Summary

Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

WLS Products (3)

mRNA	Protein	Name
NM_001002292.4	NP_001002292.3	protein wntless homolog isoform 2
NM_001193334.1	NP_001180263.1	protein wntless homolog isoform 3
NM_024911.7	NP_079187.3	protein wntless homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	24768165	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	28734904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18160348	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt protein secretion	IMP IMP: Inferred from mutant phenotype	24768165	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	16678095	GOA
involved in positive regulation of Wnt protein secretion	IMP IMP: Inferred from mutant phenotype	16678095	GOA
involved in positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16678095	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17804805	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16678095	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	24768165	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	16678095	GOA
located in early endosome	IDA IDA: Inferred from direct assay	18160348	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	24768165	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18160348	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	18160348	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WLS Protein Structure

MIG-14_Wnt-bd

0
100
200
300
400
500
541 a.a.

Protein Preferred Names	Protein Names
protein wntless homolog	G protein-coupled receptor 177

WLS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Y2H	23840749
Intra	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Anti Tag CoIP	20214800
Intra	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Ub Reconstruction	23840749
Intra	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Ub Reconstruction	28298427
Intra	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Anti Bait CoIP	20214800
Intra	WLS	Q5T9L3	OPRM1	Homo sapiens	P35372	Ub Reconstruction	20214800
Intra	WLS	Q5T9L3	SLC6A3	Homo sapiens	Q01959	Anti Tag CoIP	28734904
Intra	WLS	Q5T9L3	SLC6A3	Homo sapiens	Q01959	Pull Down	28734904

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Zaki Syndrome	ZKS Microcephaly, Progressive, With Developmental Delay, Cupped Ears, And Dysmorphic Features
Volkmann Contracture	Ischemic Contracture Volkmann'S Ischemic Contracture
Tracheal Disease	Tracheal Diseases Tracheal Anomaly Tracheal Disorders
Focal Dermal Hypoplasia	Goltz Syndrome Goltz-Gorlin Syndrome FDH FODH Dhof Goltz Gorlin Syndrome Hypoplasia, Dermal, Focal
Brain Malformations With Or Without Urinary Tract Defects	Chromosome 1p32-P31 Deletion Syndrome Nfia-Related Disorder Chromosome 1, Monosomy 1p32 BRMUTD 1p31p32 Microdeletion Syndrome Nfia Haploinsufficiency Del(1)(P31p32) Monosomy 1p31p32 Nfia-Related Disorders
Thyroid Dyshormonogenesis 4	Deiodinase Deficiency TDH4 Iodotyrosine Dehalogenase Deficiency Thyroid Hormonogenesis, Genetic Defect In, 4 Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4 Genetic Defect In Thyroid Hormonogenesis 4 Chdh4 Congenital Hypothyroidism Due To Dyshormonogenesis Type 4 Genetic Defect In Thyroid Hormonogenesis Type 4
Tracheomalacia	Congenital Tracheomalacia Congenital Major Airway Collapse Tracheomalacia, Congenital Type 1 Tracheomalacia
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome	Foxp1 Syndrome Mental Retardation With Language Impairment And With Or Without Autistic Features Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects Intellectual Disability With Language Impairment And With Or Without Autistic Features
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Familial Thyroid Dyshormonogenesis	Thyroid Dyshormonogenesis Familial Dyshormonogenetic Goiter
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15822	WLS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22087	Wls Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28607	Wls Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WLS	RGD	RGD:735139
Canis familiaris	WLS	VGNC	VGNC:48417
Mus musculus	WLS	MGD	MGI:1915401
Macaca mulatta	WLS	VGNC	VGNC:79839
Bos taurus	WLS	VGNC	VGNC:36948
Felis catus	WLS	VGNC	VGNC:67076
Others	WLS	NCBI