Gpnmb - glycoprotein (transmembrane) nmb Gene

Also Known as ipd; Dchil; DC-HIL

Species: Mus musculus

Gene Type: protein coding
Gene ID: 93695

Summary

Enables heparin binding activity and Integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; heart ventricle; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2022]

Gpnmb Products (1)

mRNA Protein Name
NM_053110.4 NP_444340.3 transmembrane glycoprotein NMB precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
11114299 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
11114299 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
11114299 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17475886 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18036345 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18036345 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
25010402 MGI
involved in regulation of tissue remodeling IMP
IMP: Inferred from mutant phenotype
25010402 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12638126 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11114299 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane glycoprotein NMB

  • dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand

  • dendritic cell-associated transmembrane protein

  • iris pigment dispersion

  • osteoactivin

Recombinant Gpnmb Proteins

Cat. No. Product Name Accession Purity
HY-P77116 GPNMB/Osteoactivin Protein, Mouse (HEK293, His) Q99P91 (K23-N502) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-141604 Glembatumumab vedotin Inhibitor ≥99.0% Phase 2
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99205 Glembatumumab 99.69% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05648 GPNMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16622 Gpnmb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23057 Gpnmb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpnmb NCBI NCBI:10457