GPNMB - glycoprotein nmb Gene

Also Known as NMB; HGFIN; PLCA3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10457

About GPNMB

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,246,775-23,275,108 (from NCBI)

This gene has 15 transcripts (splice variants), 205 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in skin (RPKM 225.4), gall bladder (RPKM 143.5) and 17 other tissues.

Summary

The protein encoded by this gene is a type I Transmembrane Glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GPNMB Products (2)

mRNA	Protein	Name
NM_001005340.2	NP_001005340.1	transmembrane glycoprotein NMB isoform a precursor
NM_002510.3	NP_002501.1	transmembrane glycoprotein NMB isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heparin binding	IDA IDA: Inferred from direct assay	19350579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12609765	GOA
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	19350579	GOA
enables syndecan binding	IPI IPI: Inferred from physical interaction	19350579	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell-cell signaling	IMP IMP: Inferred from mutant phenotype	19350579	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	19350579	GOA
involved in negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	19350579	GOA
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	19350579	GOA
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	19350579	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	20711474	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	19350579	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	22891158	GOA
involved in regulation of tissue remodeling	IDA IDA: Inferred from direct assay	25010402	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	19350579	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	12609765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPNMB Protein Structure

PKD

0
100
200
300
400
500
572 a.a.

Protein Preferred Names	Protein Names
transmembrane glycoprotein NMB	glycoprotein (transmembrane) nmb

Recombinant GPNMB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70836	GPNMB/Osteoactivin Protein, Human (HEK293, His)	Q14956-1 (A22-P486)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75950	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His)	Q14956-2 (A22-P474)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75951	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc)	Q14956-2 (A22-P474)	≥ 95%, as determined by reducing SDS-PAGE.

GPNMB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81414	GPNMB Antibody (YA1159)	IHC-P	Human
HY-P81414A	GPNMB Antibody (YA1159)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Amyloidosis, Primary Localized Cutaneous, 3	Amyloidosis Cutis Dyschromica PLCA3 Acd Primary Localized Cutaneous Amyloidosis 3 Amyloidosis Cutis Dyschromia
Lichen Amyloidosis	Amyloid Lichen Lichen Amyloidosus Amyloidosis, Primary Cutaneous
Macular Amyloidosis	Amyloidosis, Macular
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Borderline Glaucoma	Preglaucoma
Ocular Pigment Dispersion With Or Without Glaucoma	Pigment Dispersion Syndrome Glaucoma-Related Pigment Dispersion Syndrome OPDG Pds Glaucoma, Pigment-Dispersion Type Gpds1 Pigment-Dispersion Type Glaucoma Pigment-Dispersion Syndrome Glaucoma, Open-Angle
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Niemann-Pick Disease	Sphingomyelin/Cholesterol Lipidosis Niemann-Pick Diseases Lipoid Histiocytosis Sphingomyelin Lipidosis Sphingomyelinase Deficiency Disease Lipid Histiocytosis Neuronal Cholesterol Lipidosis Neuronal Lipidosis Npd Sphingomyelinase Deficiency Niemann-Pick Disease, Type A
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Takayasu'S Arteritis Idiopathic Aortitis Young Female Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Iris Disease	Iris Diseases
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-141604	Glembatumumab vedotin	Inhibitor	≥99.0%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99205	Glembatumumab		99.69%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05648	GPNMB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16622	Gpnmb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23057	Gpnmb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPNMB	MGD	MGI:1934765
Macaca mulatta	GPNMB	VGNC	VGNC:73123
Rattus norvegicus	GPNMB	RGD	RGD:71008
Felis catus	GPNMB	VGNC	VGNC:67413
Canis familiaris	GPNMB	VGNC	VGNC:41389
Bos taurus	GPNMB	VGNC	VGNC:29541
Others	GPNMB	NCBI