GPNMB Antibody (YA1159)(PBS only)

Cat. No.: HY-P81414A: Data Sheet User Guide for Antibodies
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GPNMB Antibody (YA1159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPNMB.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GPNMB Antibody (YA1159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPNMB.

Host

Rabbit

Molecular Weight

Predicted band size: 64 kDa;

Observed band size: 64 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q14956

Gene ID

10457 [NCBI]

Immunogen

Recombinant protein of human GPNMB

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Could be a melanogenic enzyme

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Melanosome membrane; Single-pass type I membrane protein; Early endosome membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006) . Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782) . Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765) . Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096) . May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:16489096, PubMed:16609006, PubMed:7814155)

Induction:Up-regulated by G-CSF/CSF3 and M-CSF/CSF1 in bone marrow mononuclear cells, hence up-regulation may be linked to differentiation

Isoforms & Post-Translational Modification：Q14956 has 2 isomers: Q14956-1: 63923 Da (predicted); Q14956-2: 62643 Da (predicted).

Research Field

Immunology

Synonyms

NMB; HGFIN

Documentation

User Guide for Antibodies (1077 KB)