2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. GPNMB Antibody (YA1159)

GPNMB Antibody (YA1159)

Cat. No.: HY-P81414
User Guide for Antibodies Technical Support

GPNMB Antibody (YA1159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPNMB.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

GPNMB Antibody (YA1159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPNMB.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 64 kDa;
Observed band size: 64 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human GPNMB
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
100-1:200
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.190.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Could be a melanogenic enzyme
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Melanosome membrane; Single-pass type I membrane protein; Early endosome membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006) . Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782) . Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765) . Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096) . May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:16489096, PubMed:16609006, PubMed:7814155)

Induction:Up-regulated by G-CSF/CSF3 and M-CSF/CSF1 in bone marrow mononuclear cells, hence up-regulation may be linked to differentiation
Isoforms & Post-Translational Modification：Q14956 has 2 isomers: Q14956-1: 63923 Da (predicted); Q14956-2: 62643 Da (predicted).
Database

Entrez Gene: 10457 Human

SwissProt: Q14956 Human

OMIM: 617920 Human

Research Field

Immunology
Synonyms
NMB; HGFIN
Documentation
User Guide for Antibodies (1077 KB)
References

GPNMB Antibody (YA1159) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GPNMB Antibody (YA1159)
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