GPNMB Antibody (YA1159)
(Synonyms: NMB; HGFIN)GPNMB Antibody (YA1159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPNMB.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.190.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 100-1:200 |
Product Details
GPNMB Antibody (YA1159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPNMB.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 64 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 64 kDa
Recombinant protein of human GPNMB
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.190.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GPNMB is a Could be a melanogenic enzyme
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Melanosome membrane; Single-pass type I membrane protein; Early endosome membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006) . Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782) . Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765) . Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096) . May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:16489096, PubMed:16609006, PubMed:7814155)
Induction:Up-regulated by G-CSF/CSF3 and M-CSF/CSF1 in bone marrow mononuclear cells, hence up-regulation may be linked to differentiation -
Isoforms & Post-Translational Modification
Q14956 has 2 isomers: Q14956-1: 63923 Da (predicted); Q14956-2: 62643 Da (predicted).
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SwissProt ID
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Synonyms
NMB; HGFIN
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Research Field
Immunology
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