CXCL17 - C-X-C motif chemokine ligand 17 Gene

Also Known as DMC; VCC1; Dcip1; VCC-1; UNQ473

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 284340

About CXCL17

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,428,278-42,442,946 (from NCBI)

This gene has 2 transcripts (splice variants) and 84 orthologues. Biased expression in stomach (RPKM 182.1), lung (RPKM 72.2) and 3 other tissues.

Summary

The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

CXCL17 Products (1)

mRNA	Protein	Name
NM_198477.3	NP_940879.1	C-X-C motif chemokine 17 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	23115081	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23115081	GOA
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	23115081	GOA
involved in positive regulation of monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	23115081	GOA
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	23115081	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IMP IMP: Inferred from mutant phenotype	23115081	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL17 Protein Structure

CXCL17

0
100
119 a.a.

Protein Preferred Names	Protein Names
C-X-C motif chemokine 17	6-Cys CXCL17

CXCL17 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXCL17	Q6UXB2	PF4	Homo sapiens	P02776	SPR	28381538
Intra	CXCL17	Q6UXB2	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CXCL17	Q6UXB2	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	CXCL17	Q6UXB2	CXCL12	Homo sapiens	P48061	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL17 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71878	CXCL17 Protein, Human	Q6UXB2 (S22-L119)	≥ 95%, as determined by reducing SDS-PAGE.

CXCL17 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89903	VCC-1 Antibody (YA9247)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Photokeratitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03390	CXCL17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18091	Cxcl17 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24565	Cxcl17 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXCL17	VGNC	VGNC:109613
Rattus norvegicus	CXCL17	RGD	RGD:1304717
Canis familiaris	CXCL17	VGNC	VGNC:49733
Mus musculus	CXCL17	MGD	MGI:2387642
Bos taurus	CXCL17	VGNC	VGNC:27852
Others	CXCL17	NCBI