Platelet Factor 4

Related Products

PF-4/CXCL4 is a member of the CXC chemokine family that is released from the alpha-granules of activated platelets. PF-4/CXCL4 binds with high affinity to heparin, with antiheparin, antiangiogenic and immunomodulatory activities. PF-4/CXCL4 plays a role in hematopoiesis and immune cell modulation. In megakaryocytes CXCL4 is synthesized, enclosed in vesicles, and transferred to the α granules from which it is secreted following platelet activation. CXCL4 expression is also found in microglia, monocytes and activated T-cells^[1]^[2].
CXCL4 shows pleiotropic biological functions. Firstly, CXCL4 activates platelets, modulates platelet aggregation and stimulates release of α-granule proteins. CXCL4 has a role in heparin-induced thrombocytopenia (HIT). Secondly, CXCL4 inhibits endothelial cell proliferation and migration, leading to suppression of angiogenesis. Thirdly, CXCL4 expresses immunomodulatory activities, such as down-regulation of IFN- production by type 1 T-helper (Th1) cells and up-regulation of IL-4, IL-5, and IL-13 in type 2 T-helper (Th2) cells. Fourthly, CXCL4 influences hematopoiesis, inhibiting megakaryocytopoiesis and the proliferation of committed erythroid and granulocyte-macrophage colonies, as well as of primitive CD34⁺ progenitors. Moreover, CXCL4 is also highly upregulated in plasmacytoid dendritic cells (pDCs) in systemic sclerosis and dendritic cells (DCs) after severe trauma^[1]^[2]^[3].

References:

[1]. Lasagni L, et al. PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. Blood. 2007 May 15;109(10):4127-34. [Content Brief]

[2]. Pieter Ruytinx, et al. CXCL4 and CXCL4L1 in cancer. Cytokine. 2018 Sep;109:65-71. [Content Brief]

[3]. Gabriele Domschke, et al. CXCL4-induced macrophages in human atherosclerosis. Cytokine. 2019 Oct;122:154141. [Content Brief]

Subscribe Now to the List of Recombinant Proteins

Platelet Factor 4 Recombinant Proteins (8)

Species:	Human (6) Mouse (2)
Tag:	His (4) Fc (1) Avi (2) Tag Free (3)
Source:	E. coli (5) HEK293 (3)

Cat. No.	Product Name / Synonyms	Species	Source

HY-P7281

PF-4/CXCL4 Protein, Human (HEK293) rHuPF-4/CXCL4; C-X-C motif chemokine 4; Oncostatin A; SCYB4	Human	HEK293
PF-4/CXCL4 is a member of the CXC chemokine family that is released from the alpha-granules of activated platelets. PF-4/CXCL4 binds with high affinity to heparin, with antiheparin, antiangiogenic and immunomodulatory activities. PF-4/CXCL4 plays a role in hematopoiesis and immune cell modulation. PF-4/CXCL4 Protein, Human (HEK293) is produced in HEK293 cells, and consists of 70 amino acids (E32-S101).

HY-P70618

PF-4/CXCL4 Protein, Human (HEK293, His) Platelet Factor 4; PF-4; C-X-C Motif Chemokine 4; Iroplact; Oncostatin-A; PF4; CXCL4; SCYB4	Human	HEK293
PF-4/CXCL4 is a member of the CXC chemokine family that is released from the alpha-granules of activated platelets. PF-4/CXCL4 binds with high affinity to heparin, with antiheparin, antiangiogenic and immunomodulatory activities. PF-4/CXCL4 plays a role in hematopoiesis and immune cell modulation. PF-4/CXCL4 Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 70 amino acids (E32-S101).

HY-P700046AF

Animal-Free PF-4/CXCL4 Protein, Human (His) C-X-C motif chemokine 4; Oncostatin A; SCYB4	Human	E. coli
The PF-4/CXCL4 protein released during platelet aggregation has a crucial impact on physiological processes. It neutralizes the anticoagulant effect of heparin with higher affinity than chondroitin 4-sulfate chains. Animal-Free PF-4/CXCL4 Protein, Human (His) is the recombinant human-derived animal-FreePF-4/CXCL4 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free PF-4/CXCL4 Protein, Human (His) is 70 a.a., with molecular weight of ~8.58 kDa.

HY-P71885

Platelet factor 4 Protein, Mouse Pf4; Cxcl4; Scyb4; Platelet factor 4; PF-4; C-X-C motif chemokine 4	Mouse	E. coli
Platelet factor 4 (PF4) is released during platelet aggregation and neutralizes the anticoagulant effect of heparin with a higher binding affinity than chondroitin 4-sulfate chains. In addition to its anticoagulant effects, PF4 induces neutrophil and monocyte chemotaxis, thereby promoting immune responses. Platelet factor 4 Protein, Mouse is the recombinant mouse-derived Platelet factor 4 protein, expressed by E. coli , with tag free. The total length of Platelet factor 4 Protein, Mouse is 76 a.a., with molecular weight of ~8.2-12 kDa.

HY-P78289

PF-4/CXCL4 Protein, Mouse (HEK293, Fc) PF-4; Oncostatin-A; CXCL4; SCYB4; Iroplact; MGC138298	Mouse	HEK293
PF-4/CXCL4 is a member of the CXC chemokine family that is released from the alpha-granules of activated platelets. PF-4/CXCL4 binds with high affinity to heparin, with antiheparin, antiangiogenic and immunomodulatory activities. PF-4/CXCL4 plays a role in hematopoiesis and immune cell modulation. PF-4/CXCL4 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 76 amino acids (V30-S105).

HY-P700981

PF-4/CXCL4 Protein, Human (Biotinylated, His-Avi) PF-4; Oncostatin-A; CXCL4; SCYB4; Iroplact; MGC138298	Human	E. coli
Wnt-10b protein is a signaling molecule that plays a key role in embryonic development and tissue homeostasis. It is involved in regulating cell proliferation, differentiation and migration. PF-4/CXCL4 Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived PF-4/CXCL4 protein, expressed by E. coli , with C-Avi, N-His labeled tag. The total length of PF-4/CXCL4 Protein, Human (Biotinylated, His-Avi) is 70 a.a., with molecular weight of 13 kDa.

HY-P700703

PF-4/CXCL4 Protein, Human (His-Avi) PF-4; Oncostatin-A; CXCL4; SCYB4; Iroplact; MGC138298	Human	E. coli
Wnt-10b protein is a signaling molecule that plays a key role in embryonic development and tissue homeostasis. It is involved in regulating cell proliferation, differentiation and migration. PF-4/CXCL4 Protein, Human (His-Avi) is the recombinant human-derived PF-4/CXCL4 protein, expressed by E. coli , with C-Avi, N-His labeled tag. The total length of PF-4/CXCL4 Protein, Human (His-Avi) is 70 a.a., with molecular weight of 10.68 kDa.

HY-P76853

PF-4/CXCL4 Protein, Human C-X-C motif chemokine 4; Oncostatin A; SCYB4	Human	E. coli
PF-4/CXCL4 is a member of the CXC chemokine family that is released from the alpha-granules of activated platelets. PF-4/CXCL4 binds with high affinity to heparin, with antiheparin, antiangiogenic and immunomodulatory activities. PF-4/CXCL4 plays a role in hematopoiesis and immune cell modulation. PF-4/CXCL4 Protein, Human is produced in E. coli , and consists of 70 amino acids (E32-S101).

Name
Email *

	Sorry, but the email address you supplied was invalid.

Platelet Factor 4

Platelet Factor 4

Subscribe Now to the List of Recombinant Proteins

Platelet Factor 4 Recombinant Proteins (8)