Trip13 - thyroid hormone receptor interactor 13 Gene

Also Known as D13Ertd328e; 2410002G23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 69716

Summary

Enables identical protein binding activity. Involved in double-strand break repair; gamete generation; and meiosis I. Acts upstream of or within gamete generation. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (Thyroid Hormone Receptor interactor 13). [provided by Alliance of Genome Resources, Apr 2022]

Trip13 Products (1)

mRNA	Protein	Name
NM_027182.2	NP_081458.1	pachytene checkpoint protein 2 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28256593	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	17696610	MGI
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	20711356	MGI
acts upstream of or within female meiosis I	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within oocyte maturation	IGI IGI: Inferred from genetic interaction	17696610	MGI
acts upstream of or within oocyte maturation	IMP IMP: Inferred from mutant phenotype	17696610	MGI
involved in oogenesis	IMP IMP: Inferred from mutant phenotype	20711356	MGI
acts upstream of or within reciprocal meiotic recombination	IMP IMP: Inferred from mutant phenotype	17696610	MGI
involved in reciprocal meiotic recombination	IMP IMP: Inferred from mutant phenotype	20711356	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	17696610	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	20711356	MGI
involved in synaptonemal complex assembly	IMP IMP: Inferred from mutant phenotype	20711356	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	17696610	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pachytene checkpoint protein 2 homolog	TR-interacting protein 13 TRIP-13 thyroid receptor-interacting protein 13

Trip13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Trip13	Q3UA06	Ttc5	Mus musculus	Q99LG4	Anti Tag CoIP	28256593
Intra	Trip13	Q3UA06	Ttc5	Mus musculus	Q99LG4	Y2H	28256593

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130603	DCZ0415		99.81%	Unkown
HY-Q04764	TI17		95.97%	Unkown
HY-157331	DCZ5418	Inhibitor	99.62%	Unkown
HY-RS15079	TRIP13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162999	TRIP13-IN-1	Inhibitor	/	Unkown
HY-RS17151	Trip13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23601	Trip13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990867	Anti-CD220/Insulin Receptor Antibody (IR 83-22)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trip13	NCBI	NCBI:9319