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Cat. No.: HY-186138A

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TR modulator-1 bromide

TR modulator-1 (compound 10c) bromide is a selective thyroid hormone receptor (TR) modulator. TR modulator-1 bromide can be used in the research of hyperthyroidism and thyrotoxicosis.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₀BrF₃N₅O₄
Molecular Weight:543.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TR modulator-1 bromide Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TR modulator-1 (compound 10c) bromide is a selective thyroid hormone receptor (TR) modulator. TR modulator-1 bromide can be used in the research of hyperthyroidism and thyrotoxicosis^[1].

Chemical Information

Molecular Weight 543.31
Formula C₂₁H₂₀BrF₃N₅O₄
SMILES

O=C(N1NC(CC12CCN(CC2)C3=CC=C([N+]([O-])=O)C=C3)=O)NC4=CC=CC(C(F)(F)F)=C4.[Br]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (9.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8406 mL

9.2028 mL

18.4057 mL

5 mM

0.3681 mL

1.8406 mL

3.6811 mL

10 mM

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Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Herbert H. Samuels, et al. Hydrazide compounds as thyroid hormone receptor modulators and uses thereof. WO2008130637A1. 2008-10-30.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8406 mL	9.2028 mL	18.4057 mL	46.0142 mL
DMSO	5 mM	0.3681 mL	1.8406 mL	3.6811 mL	9.2028 mL

Keywords

100 mg

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