2,4,6-Triiodophenol
Based on 1 Customer Validation
2,4,6-Triiodophenol is an orally active and potent leukotriene B4 (LTB4) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 609-23-4
- 分子式: C6H3I3O
- 分子量:471.80
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Aging Compound Library
HY-L034
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Oxygen Sensing Compound Library
HY-L045
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Orally Active Compound Library
HY-L061
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
2,4,6-Triiodophenol (5-50 μM; 0-100 h) impairs the quality of pre-implantation mouse embryos in a dose-dependent manner, inducing decline of both total and trophectoderm cell numbers[2].
2,4,6-Triiodophenol (5 μM; 85 h) shows increasement of apoptotic cells in mouse pre-implantation embryos[2].
2,4,6-Triiodophenol (5-50 μM; 100 h) induces oxidative stress in mouse pre-implantation embryos[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse blastocyst cells
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Concentration:5 μM
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Incubation Time:85 hours
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Result:Showed signals of activated Caspase-3/7.
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Cell Line:Mouse blastocyst cells
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Concentration:5-50 μM
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Incubation Time:100 hours
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Result:Resulted in marked increase of oxygen species (ROS) treated with high dose of 2,4,6-Triiodophenol.
化学情報
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CAS 番号 609-23-4
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性状 Solid
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分子量 471.80
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分子式 C6H3I3O
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Color Off-white to pink
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SMILES
OC1=C(I)C=C(I)C=C1I
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別名
2,4,6-トリヨードフェノール
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 250 mg/mL (529.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Liu S, et al. 2,4,6-triiodophenol exhibits embryotoxicity to pre-implantation mouse embryos in an in vitro exposure model. Ecotoxicol Environ Saf. 2022 Aug;241:113745. [Content Brief]
[2]. Trocóniz IF, et al. Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor. Pharm Res. 2006 Jul;23(7):1533-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1195 mL | 10.5977 mL | 21.1954 mL | 52.9886 mL |
| 5 mM | 0.4239 mL | 2.1195 mL | 4.2391 mL | 10.5977 mL | |
| 10 mM | 0.2120 mL | 1.0598 mL | 2.1195 mL | 5.2989 mL | |
| 15 mM | 0.1413 mL | 0.7065 mL | 1.4130 mL | 3.5326 mL | |
| 20 mM | 0.1060 mL | 0.5299 mL | 1.0598 mL | 2.6494 mL | |
| 25 mM | 0.0848 mL | 0.4239 mL | 0.8478 mL | 2.1195 mL | |
| 30 mM | 0.0707 mL | 0.3533 mL | 0.7065 mL | 1.7663 mL | |
| 40 mM | 0.0530 mL | 0.2649 mL | 0.5299 mL | 1.3247 mL | |
| 50 mM | 0.0424 mL | 0.2120 mL | 0.4239 mL | 1.0598 mL | |
| 60 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8831 mL | |
| 80 mM | 0.0265 mL | 0.1325 mL | 0.2649 mL | 0.6624 mL | |
| 100 mM | 0.0212 mL | 0.1060 mL | 0.2120 mL | 0.5299 mL |
2,4,6-Triiodophenol 関連分類
HY-W073687 関連分類
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