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製品番号: HY-146433

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Anticancer agent 55

Anticancer agent 55 is a potent anticancer agent. Anticancer agent 55 shows anticancer activity via reducing the cell viability and cell migration in a dose-dependent manner. Anticancer agent 55 induces apoptosis. Anticancer agent 55 has the potential for the research of prostate cancer and breast cancer.

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CAS 番号: 2408800-91-7
分子式: C₂₈H₂₁Br₂FN₂O₂
分子量:596.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Anticancer agent 55 構造式

CAS 番号: 2408800-91-7

容量

価格（税別）

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数量

Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	1.95 μM Compound: 3h	Cytotoxicity against human MCF7 cells assessed as reduction cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction cell viability incubated for 48 hrs by MTS assay	[PMID: 31901746]
PC-3	IC₅₀	1.18 μM Compound: 3h	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 31901746]

体外実験

Anticancer agent 55 (compound 3h) (0-100 μM; 48 h) inhibits cell viability with IC₅₀s of 1.18 μM and 1.95 μM for PC-3, MCF-7 cells, respectively^[1].
Anticancer agent 55 (0, 1, 3, 10 μM; 24 h) inhibits cell migration of PC-3 cells and MCF-7 cells in a dose-dependent manner^[1].
Anticancer agent 55 (0, 1, 3, 10 μM; 12, 24 h) induces apoptosis by increases the caspase-3 activity and cleaved PARP levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC-3, MCF-7 cells
Concentration:

0-100 µM
Incubation Time:

48 h
Result:

Significantly inhibited cell viability of PC-3, MCF-7 cells with IC₅₀s of 1.18 µM and 1.95 µM, respectively.

Apoptosis Analysis^[1]

Cell Line:

PC-3, MCF-7 cells
Concentration:

0, 1, 3, 10 µM
Incubation Time:

PC-3 for 12 h; MCF-7 for 24 h
Result:

Induced apoptosis by increased the caspase-3 activity in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

PC-3, MCF-7 cells
Concentration:

0, 1, 3, 10 µM
Incubation Time:

PC-3 for 12 h; MCF-7 for 24 h
Result:

Increased cleaved PARP levels in a dose-dependent manner in PC-3 and MCF-7 cells.

化学情報

CAS 番号 2408800-91-7
分子量 596.28
分子式 C₂₈H₂₁Br₂FN₂O₂
SMILES

O=C(C1=CC=CC=C1)C[N+]2=CC3=CC=CN3[C@@H](C2C4=CC=C(C=C4)Br)C(C5=CC=C(C=C5)F)=O.[Br-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Seo Y, et al. Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells. Eur J Med Chem. 2020 Feb 15;188:111988. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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