162303-59-5
Chemical Structure
EDTA-AM
Synonym(s): EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
- CAS 番号: 162303-59-5
- Formula:C22H32N2O16
- Molecular Weight:580.49
IUPAC Name: tetrakis(acetoxymethyl) 2,2',2'',2'''-(ethane-1,2-diylbis(azanetriyl))tetraacetate
InChIKey: BYZOHUNEZPRPFB-UHFFFAOYSA-N
SMILES: O=C(C)OCOC(CN(CCN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=O
Biological Activity: EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation[1][2].
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EDTA-AM | 98.0% | EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation. | ||||||||||||||||||||
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- [1]. Watkins CS, et.al. Effects on K+ currents in rat cerebellar granule neurones of a membrane-permeable analogue of the calcium chelator BAPTA. Br J Pharmacol. 1996 Aug;118(7):1772-8. [Content Brief]
- [2]. Maeshima K, et.al. A Transient Rise in Free Mg2+Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation. Curr Biol. 2018 Feb 5;28(3):444-451.e6. [Content Brief]
Keywords
