2913578-04-6
Chemical Structure
Adenosine receptor antagonist 6
- CAS 番号: 2913578-04-6
- Formula:C18H16N6O
- Molecular Weight:332.36
IUPAC Name: (S)-1-amino-N-(1-(pyridin-2-yl)ethyl)benzo[4,5]imidazo[1,2-a]pyrazine-3-carboxamide
InChIKey: VQPVINIXDISQMT-NSHDSACASA-N
SMILES: O=C(C1=CN2C3=CC=CC=C3N=C2C(N)=N1)N[C@@H](C)C4=NC=CC=C4
Biological Activity: Adenosine receptor antagonist 6 is an orally active and selective A2A adenosine receptor (A2AAR) antagonist, with a Ki of 19.18 nM. Adenosine receptor antagonist 6 inhibits 5’-N-ethylcarboxamide adenosine (NECA) (HY-103173)-mediated cAMP production (IC50 = 0.089 μM) and immunosuppression, while promoting IL-2 and IFN-γ secretion. Adenosine receptor antagonist 6 abolishes the immunosuppressive effects of adenosine on T-cell activation and cytokine release. Adenosine receptor antagonist 6 inhibits tumor growth in a CT26/MC38 xenograft model. Adenosine receptor antagonist 6 can be used for the study of colon cancer[1].
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Adenosine receptor antagonist 6 | Adenosine receptor antagonist 6 is an orally active and selective A2A adenosine receptor (A2AAR) antagonist, with a Ki of 19.18 nM. Adenosine receptor antagonist 6 inhibits 5’-N-ethylcarboxamide adenosine (NECA) (HY-103173)-mediated cAMP production (IC50 = 0.089 μM) and immunosuppression, while promoting IL-2 and IFN-γ secretion. Adenosine receptor antagonist 6 abolishes the immunosuppressive effects of adenosine on T-cell activation and cytokine release. Adenosine receptor antagonist 6 inhibits tumor growth in a CT26/MC38 xenograft model. Adenosine receptor antagonist 6 can be used for the study of colon cancer. | |||||||||||||||||||||
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Keywords
