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PPP1R15A - protein phosphatase 1 regulatory subunit 15A Gene

Also Known as GADD34

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23645

About PPP1R15A

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,872,421-48,876,058 (from NCBI)

This gene has 5 transcripts (splice variants), 112 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 214.4), gall bladder (RPKM 51.1) and 23 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with Apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

PPP1R15A Products (1)

mRNA	Protein	Name
NM_014330.5	NP_055145.3	protein phosphatase 1 regulatory subunit 15A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	11564868	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11517336	GOA
enables protein phosphatase 1 binding	IDA IDA: Inferred from direct assay	11564868	GOA
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	12556489	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	12556489	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in protein localization to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	12556489	GOA
involved in regulation of translational initiation	IDA IDA: Inferred from direct assay	11564868	GOA
involved in regulation of translational initiation in response to stress	IDA IDA: Inferred from direct assay	11564868	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	12556489	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21518769	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21518769	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12556489	GOA
located in membrane	IDA IDA: Inferred from direct assay	21518769	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	21518769	GOA
part of protein phosphatase type 1 complex	IDA IDA: Inferred from direct assay	11564868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R15A Protein Structure

PP1c_bdg

0
200
400
600
674 a.a.

Protein Preferred Names	Protein Names
protein phosphatase 1 regulatory subunit 15A	growth arrest and DNA damage-inducible protein GADD34

PPP1R15A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	PPP1R15A	O75807	PPP1R1A	Homo sapiens	Q13522	Pull Down	11564868
Intra	PPP1R15A	O75807	PPP1R1A	Homo sapiens	Q13522	Y2H	11564868
Intra	PPP1R15A	O75807	PPP1CA	Homo sapiens	P62136	Y2H	15231748
Intra	PPP1R15A	O75807	PPP1CA	Homo sapiens	P62136	FPS	26095357
Intra	PPP1R15A	O75807	PPP1CA	Homo sapiens	P62136	Pull Down	29109149
Intra	PPP1R15A	O75807	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	29109149
Intra	PPP1R15A	O75807	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	26095357
Intra	PPP1R15A	O75807	TARDBP	Homo sapiens	Q13148	Pull Down	29109149
Intra	PPP1R15A	O75807	TARDBP	Homo sapiens	Q13148	Anti Tag CoIP	29109149

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus	Wolcott-Rallison Syndrome Med-Iddm Syndrome Iddm-Med Syndrome Wolcott Rallison Syndrome WRS Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Charcot-Marie-Tooth Disease, Demyelinating, Type 1b	Charcot-Marie-Tooth Disease Type 1b CMT1B Hereditary Motor And Sensory Neuropathy Ib Hmsn Ib Hmsn1b Peroneal Muscular Atrophy Charcot-Marie-Tooth Disease, Type 1b Charcot-Marie-Tooth Disease Slow Nerve Conduction Type Linked To Duffy Charcot-Marie-Tooth Neuropathy Type 1b Charcot-Marie-Tooth Disease, Type Ib Hereditary Motor And Sensory Neuropathy I Hmsn I Hmsn1 Charcot-Marie-Tooth Neuropathy, Type 1b Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1b Autosomal Dominant Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 1b Charcot-Marie-Tooth Disease 1b Charcot-Marie-Tooth Disease Demyelinating Type 1b Hmsn Type I Hereditary Motor And Sensory Neuropathy Type I Charcot-Marie-Tooth Disease
Leukoencephalopathy With Vanishing White Matter	Cree Leukoencephalopathy Vanishing White Matter Disease Ovarioleukodystrophy Vanishing White Matter Leukodystrophy Childhood Ataxia With Central Nervous System Hypomyelinization Cach Cach Syndrome Myelinosis Centralis Diffusa VWM Cle Childhood Ataxia With Central Nervous System Hypomyelination Childhood Ataxia With Diffuse Central Nervous System Hypomyelination Cach/Vwm Cach/Vwm Syndrome Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter Cree Leukoencehalopathy Late Infantile Cach Syndrome Juvenile Or Adult Cach Syndrome Congenital Or Early Infantile Cach Syndrome Leukodystrophy With Vanishing White Matter
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-111022	Icerguastat	Inhibitor	99.93%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-18956	(E/Z)-Icerguastat	Inhibitor	99.44%	Unkown
HY-RS10986	PPP1R15A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-110365	Icerguastat Carbonate	Inhibitor	/	Unkown
HY-18956B	(E/Z)-Icerguastat acetate	Inhibitor	/	Unkown
HY-18956A	(E/Z)-Icerguastat hydrochloride	Inhibitor	/	Unkown
HY-RS17569	Ppp1r15a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24029	Ppp1r15a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	PPP1R15A	VGNC	VGNC:53754
Mus musculus	PPP1R15A	MGD	MGI:1927072
Bos taurus	PPP1R15A	VGNC	VGNC:33228
Rattus norvegicus	PPP1R15A	RGD	RGD:621526
Macaca mulatta	PPP1R15A	VGNC	VGNC:76254
Others	PPP1R15A	NCBI