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Icerguastat Carbonate

(Synonyms: Sephin1 Carbonate; IFB-088 Carbonate)
4 Cited Publications
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Based on 4 publication(s) in Google Scholar

Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect.

For research use only. We do not sell to patients.

  • CAS No.: 1883549-35-6
  • Formula: C9H11ClN4O3
  • Molecular Weight:258.66
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Icerguastat Carbonate Chemical Structure
    Icerguastat Carbonate Chemical Structure
  • Experimental Validation Results for Icerguastat Carbonate
  • Experimental Validation Results for Icerguastat Carbonate
  • Experimental Validation Results for Icerguastat Carbonate
  • Experimental Validation Results for Icerguastat Carbonate
  • Experimental Validation Results for Icerguastat Carbonate
CAS No.: 1883549-35-6
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  • Icerguastat Carbonate Chemical Structure
    Icerguastat Carbonate Chemical Structure
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    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433. [Abstract]

    Customer Validation
     Icerguastat (Sephin1) (0.5 μM; 14 d) significantly reduced calcium deposition by 47% and decreased calcium concentration by 40% in AVIC treated with OGM.

  • 1/16

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433. [Abstract]

    Customer Validation
     Icerguastat (Sephin1) (0.5 μM; 14 d) markedly reduced the protein levels of calcification markers OPN and Runx2 in AVICs treated with OGM.

  • 1/16

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433. [Abstract]

    Customer Validation
     Icerguastat (Sephin1) (1 mg/kg; i.p.; once daily for 10 d) significantly alleviated aortic stenosis in CAVD mice subjected to the adenine/Vitamin D regimen, as evidenced by marked reductions in transvalvular peak jet velocity and transaortic valve pressure.

  • 1/16

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433. [Abstract]

    Customer Validation
     Icerguastat (Sephin1) (1 mg/kg; i.p.; once daily for 10 d) led to the observed mitigation of calcified nodule formation in the AVs of CAVD mice.

  • 1/16

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jun 30.

    Customer Validation
     Icerguastat (Sephin1) (10 mg/kg; i.p.; once daily for 28 d) significantly improved the sensorimotor coordination and fatigue resistance of ICH (intracerebral hemorrhage) mice.

  • Icerguastat Carbonate