2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Icerguastat Carbonate

Icerguastat Carbonate  (Synonyms: Sephin1 Carbonate; IFB-088 Carbonate)

Cat. No.: HY-110365
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Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect.

For research use only. We do not sell to patients.

CAS No. : 1883549-35-6

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Icerguastat Carbonate Related Antibodies

Top Publications Citing Use of Products
Cell Imaging/Staining
WB
In Vivo Efficacy Study
Histological Imaging/Staining

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433.  [Abstract]

    Icerguastat (Sephin1) (0.5 μM; 14 d) significantly reduced calcium deposition by 47% and decreased calcium concentration by 40% in AVIC treated with OGM.

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433.  [Abstract]

    Icerguastat (Sephin1) (0.5 μM; 14 d) markedly reduced the protein levels of calcification markers OPN and Runx2 in AVICs treated with OGM.

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433.  [Abstract]

    Icerguastat (Sephin1) (1 mg/kg; i.p.; once daily for 10 d) significantly alleviated aortic stenosis in CAVD mice subjected to the adenine/Vitamin D regimen, as evidenced by marked reductions in transvalvular peak jet velocity and transaortic valve pressure.

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: JACC Basic Transl Sci. 2025 Dec 15;11(1):101433.  [Abstract]

    Icerguastat (Sephin1) (1 mg/kg; i.p.; once daily for 10 d) led to the observed mitigation of calcified nodule formation in the AVs of CAVD mice.

    Icerguastat Carbonate purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jun 30.

    Icerguastat (Sephin1) (10 mg/kg; i.p.; once daily for 28 d) significantly improved the sensorimotor coordination and fatigue resistance of ICH (intracerebral hemorrhage) mice.

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    Description

    Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3].

    Clinical Trial
    Molecular Weight

    258.66

    Formula

    C9H11ClN4O3
    CAS No.
    SMILES

    ClC1=C(C=CC=C1)/C=N/NC(N)=N.OC(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Icerguastat Carbonate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Icerguastat1883549-35-6Sephin1IFB-088Sephin 1Sephin-1IFB088IFB 088PhosphatasephosphatasestressERproteinmisfoldingsclerosiseIF2αprionInhibitorinhibitorinhibit

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