ITGAD - integrin subunit alpha D Gene

Also Known as ADB2; CD11D

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3681

About ITGAD

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,393,335-31,426,505 (from NCBI)

This gene has 3 transcripts (splice variants), 113 orthologues and 17 paralogues. Biased expression in spleen (RPKM 11.2), lymph node (RPKM 2.1) and 2 other tissues.

Summary

This gene belongs to the beta-2 Integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the Integrin subunit alpha X gene, another member of the Integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

ITGAD Products (2)

mRNA Protein Name
NM_001318185.2 NP_001305114.1 integrin alpha-D isoform 1 precursor
NM_005353.3 NP_005344.2 integrin alpha-D isoform 2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence 参考文献 由来
involved in heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
20563599 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGAD Protein Structure

VWA

VWA: von Willebrand factor type A domain (150 - 328)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (614 - 1001)

Integrin_alpha

Integrin_alpha: Integrin alpha cytoplasmic region (1124 - 1137)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1161 a.a.
Protein Preferred Names Protein Names

integrin alpha-D

  • CD11 antigen-like family member D

関連疾患

Diseases Alias
Leukocyte Adhesion Deficiency, Type I

  • Leukocyte Adhesion Deficiency

  • Leukocyte Adhesion Deficiency 1

  • LAD1

  • Lad

  • Lymphocyte Function-Associated Antigen 1 Immunodeficiency

  • Leukocyte Adhesion Deficiency Type I

  • Leukocyte Adhesion Deficiency Type 1

  • Linear Iga Bullous Dermatosis

  • Linear Iga Dermatosis

  • Leukocyte-Adhesion Deficiency Syndrome

  • Lfa1 Immunodeficiency

  • Congenital Leukocyte Adherence Deficiency

  • Lad-I

  • Linear Iga Disease

  • Leukocyte Adhesion Deficiency Syndrome

  • Lad 1

  • Lfa 1 Immunodeficiency

  • Linear Immunoglobulin A Dermatosis

  • Leucocyte Adhesion Deficiency Type 1

  • Leukocyte Adhesion Molecule Deficiency Type 1
Chronic Monocytic Leukemia

  • Leukemia, Myeloid

  • Leukemia, Monocytic, Chronic
Leukocyte Adhesion Deficiency, Type Iii

  • Leukocyte Adhesion Deficiency 3

  • LAD3

  • Leukocyte Adhesion Deficiency 1 Variant

  • Lad1v

  • Integrin Activation Deficiency Disease

  • Iadd

  • Leukocyte Adhesion Deficiency Type Iii

  • Lad1 Variant

  • Lad-1 Variant

  • Lad-Iii

  • Leukocyte Adhesion Deficiency-1 Variant

  • Leukocyte Adhesion Deficiency Type 1
Histiocytic And Dendritic Cell Cancer

  • Histiocytic And Dendritic Cell
Histiocytic Sarcoma

  • Malignant Histiocytosis
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Spinal Muscular Atrophy, Type Iv

  • SMA4

  • Spinal Muscular Atrophy, Adult Form

  • Spinal Muscular Atrophy 4

  • Spinal Muscular Atrophy-4

  • Adult Spinal Muscular Atrophy

  • Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive

  • Proximal Spinal Muscular Atrophy Type 4

  • Sma Type 4

  • Sma Type Iv

  • Sma-Iv

  • Sma Iv

  • Spinal Muscular Atrophy Adult Form

  • Spinal Muscular Atrophy Proximal Adult Autosomal Recessive

  • Spinal Muscular Atrophy Type Iv

  • Atrophy, Muscular, Spinal, Type Iv

  • Myelopathic Muscular Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06957 ITGAD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22577 Itgad Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29095 Itgad Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P992050 Anti-ITGAD Antibody Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus ITGAD VGNC VGNC:55055
Mus musculus ITGAD MGD MGI:3578624
Rattus norvegicus ITGAD RGD RGD:71075
Others ITGAD NCBI