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CLEC2A - C-type lectin domain family 2 member A Gene

Also Known as KACL; PILAR; UNQ5792; INPE5792

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 387836

About CLEC2A

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,877,742-9,932,370 (from NCBI)

This gene has 2 transcripts (splice variants), 315 orthologues and 23 paralogues. Restricted expression toward skin (RPKM 6.7).

Summary

CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]

CLEC2A Products (2)

mRNA	Protein	Name
NM_001130711.2	NP_001124183.1	C-type lectin domain family 2 member A isoform 1
NM_207375.3	NP_997258.1	C-type lectin domain family 2 member A isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	20194751	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20194751	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC2A Protein Structure

Lectin_C

0
100
174 a.a.

Protein Preferred Names	Protein Names
C-type lectin domain family 2 member A	keratinocyte-associated C-type lectin

CLEC2A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CLEC2A	Q6UVW9	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	CLEC2A	Q6UVW9	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	CLEC2A	Q6UVW9	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CLEC2A	Q6UVW9	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CLEC2A	Q6UVW9	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CLEC2A	Q6UVW9	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	CLEC2A	Q6UVW9	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	CLEC2A	Q6UVW9	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	CLEC2A	Q6UVW9	TEX29	Homo sapiens	Q8N6K0	Validated Y2H	32296183
Intra	CLEC2A	Q6UVW9	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	CLEC2A	Q6UVW9	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Pilar Sheath Acanthoma	Acanthoma, Pilar Sheath
Lichen Nitidus	Pinkus' Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS02787	CLEC2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	CLEC2A	VGNC	VGNC:71329
Mus musculus	CLEC2A	MGD	MGI:3522133
Rattus norvegicus	CLEC2A	RGD	RGD:1588698
Others	CLEC2A	NCBI