SPACA1 - sperm acrosome associated 1 Gene

Also Known as SAMP32

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 81833

About SPACA1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:88,046,901-88,066,838 (from NCBI)

This gene has 3 transcripts (splice variants) and 116 orthologues. Restricted expression toward testis (RPKM 11.4).

Summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

SPACA1 Products (1)

mRNA	Protein	Name
NM_030960.3	NP_112222.1	sperm acrosome membrane-associated protein 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sperm acrosome membrane-associated protein 1	sperm acrosomal membrane-associated protein 32

SPACA1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SPACA1	Q9HBV2	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	SPACA1	Q9HBV2	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	SPACA1	Q9HBV2	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Atrophy Of Prostate
Chronic Salpingitis
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Oligoasthenoteratozoospermia	Oat Oligoasthenoteratospermia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS13615	SPACA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29468	Spaca1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	SPACA1	MGD	MGI:1914902
Macaca mulatta	SPACA1	VGNC	VGNC:77924
Rattus norvegicus	SPACA1	RGD	RGD:1560284
Felis catus	SPACA1	VGNC	VGNC:65590
Bos taurus	SPACA1	VGNC	VGNC:35161
Canis familiaris	SPACA1	VGNC	VGNC:46692
Others	SPACA1	NCBI