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GFM2 - GTP dependent ribosome recycling factor mitochondrial 2 Gene

Also Known as RRF; EFG2; RRF2; MRRF2; hEFG2; MST027; RRF2mt; EF-G2mt; MSTP027; mEF-G 2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 84340

About GFM2

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:74,721,206-74,767,117 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues, 18 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 9.4), testis (RPKM 9.2) and 25 other tissues.

Summary

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GFM2 Products (4)

mRNA	Protein	Name
NM_001281302.2	NP_001268231.1	ribosome-releasing factor 2, mitochondrial isoform 4
NM_032380.5	NP_115756.2	ribosome-releasing factor 2, mitochondrial isoform 1
NM_170681.3	NP_733781.1	ribosome-releasing factor 2, mitochondrial isoform 3
NM_170691.3	NP_733792.1	ribosome-releasing factor 2, mitochondrial isoform 2

GFM2 Protein Structure

GTP_EFTU

GTP_EFTU_D2

EFG_II

EFG_IV

EFG_C

0
200
400
600
779 a.a.

Protein Preferred Names	Protein Names
ribosome-releasing factor 2, mitochondrial	G elongation factor mitochondrial 2

GFM2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	GFM2	Q969S9	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	GFM2	Q969S9	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	GFM2	Q969S9	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	GFM2	Q969S9	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	GFM2	Q969S9	TRIM9	Homo sapiens	Q9C026	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 39	COXPD39 Combined Oxidative Phosphorylation Defect Type 39 Gfm2-Related Combined Oxidative Phosphorylation Defect
Mitochondrial Disease	Mitochondrial Diseases Mitochondrial Disorder
Combined Oxidative Phosphorylation Deficiency 3	Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3 COXPD3 Encephalomyopathy, Respiratory Failure, And Lactic Acidosis Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis Fatal Mitochondrial Disease Due To Coxpd3 Concentric Cardiomyopathy Hypotonia And Lactic Acidosis Encephalomyopathy Respiratory Failure And Lactic Acidosis Encephalomyopathy With Respiratory Failure And Lactic Acidosis Combined Oxidative Phosphorylation Deficiency, Type 3
Combined Oxidative Phosphorylation Deficiency 1	Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1 COXPD1 Early Fatal Progressive Hepatoencephalopathy Hepatoencephalopathy Due To Coxpd1 Combined Oxidative Phosphorylation Deficiency, Type 1 Hepatoencephalopathy, Early Fatal Progressive Hepatoencephalopathy Early Fatal Progressive
Hyperlucent Lung	Lung, Hyperlucent
Combined Oxidative Phosphorylation Deficiency
Deafness, Aminoglycoside-Induced	Streptomycin Ototoxicity Deafness, Mitochondrial, Modifier Of Aminoglycoside-Induced Deafness Deafness, Streptomycin-Induced Streptomycin-Induced Deafness DFNI
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS05381	GFM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22182	Gfm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28704	Gfm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	GFM2	RGD	RGD:1309854
Mus musculus	GFM2	MGD	MGI:2444783
Canis familiaris	GFM2	VGNC	VGNC:41184
Felis catus	GFM2	VGNC	VGNC:62525
Macaca mulatta	GFM2	VGNC	VGNC:72808
Bos taurus	GFM2	VGNC	VGNC:29328
Others	GFM2	NCBI