3 Results for "

inhibitor-kit

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "inhibitor-kit" in MCE Product Catalog:

1
WNTinib
WNTinib
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1 Cited Publications
製品番号: HY-160765
CAS 番号: 2770091-44-4
別名: APS-8-100-2
Target:  

Wnt Apoptosis

研究分野:  

Cancer

WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation .
Barzolvolimab
Barzolvolimab
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製品番号: HY-P99462
CAS 番号: 2438203-51-9
別名: CDX-0159

Target:  

c-Kit

研究分野:  

Inflammation/Immunology

Barzolvolimab is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .
KIT/PDGFRA-IN-1
KIT/PDGFRA-IN-1
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製品番号: HY-170911
Target:  

PDGFR

研究分野:  

Cancer

KIT/PDGFRA-IN-1 (compound 19) is a stem cell growth factor receptor (KIT) and platelet-derived growth factor receptor alpha (PDGFRA) inhibitor. KIT/PDGFRA-IN-1 inhibits KIT-wt, KIT-D816H, KIT-T670I, PDGFRA-wt, PDGFRA-D842V, PDGFRA-T674I and PDGFRA-G680R with IC50s of 2.3, 12, 492, 0.8, 99.9, 42.3, and 4.3 μM, respectively. KIT/PDGFRA-IN-1 inhibits GIST-T1, T1-a-D842V and GIST-48B cells (PDGFR- and KIT-Mutant GIST cell Lines) with GR50s of 12, 8900, ≥10 000 nM, respectively .
Assay Types