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製品番号: HY-Y0683A

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Petrolatum (white)

(別名: ペトロラタム白色)

カスタマーレビュー

Based on 1 Customer Validation

Petrolatum (white) is mainly composed of hydrocarbons, possesses strong water resistance and moisturizing properties, and is commonly used as a pharmaceutical excipient. Petrolatum (white) penetrates into stratum corneum cells, improves skin barrier function, repairs epidermal structure, and reduces transepidermal water loss and the risk of skin damage. Petrolatum (white) induces the expression of antimicrobial peptides, innate immune genes, filaggrin and loricrin. Petrolatum (white) is used in research on atopic dermatitis and post-operative skin infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99%
CAS 番号: 8009-03-8

保管条件:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Petrolatum (white) 構造式

CAS 番号: 8009-03-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Petrolatum (thin layer; once (acetone-perturbed skin), twice daily for 3 days (normal skin)) (white) penetrates all levels of the stratum corneum in both normal and acetone-perturbed post-mortem hairless mouse stratum corneum, localizing to intercellular spaces where it expands domains, separates bilayers, and forms distinct nonlamellar regions, without entering nucleated epidermal layers^[2].
Petrolatum (100%; 48 h occlusion, biopsy at 72 h) (white) upregulates the expression of antimicrobial peptides (S100A8, S100A9, DEFB4A, LCN2, PI3, CCL20) and innate immune genes, enhances the expression of filaggrin (FLG) and loricrin (LOR) and thickens the stratum corneum in human skin, and reduces the infiltration of CD3⁺/CD8⁺ T cells and CD1c⁺ dendritic cells in nonlesional atopic dermatitis skin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Petrolatum (Thin layer; topical; single application, twice daily; 3 days) penetrates all levels of the murine stratum corneum via intercellular domains, dramatically reduces TEWL immediately after application to acetone-damaged skin, and does not impede endogenous barrier recovery^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 8009-03-8
性状 <38°C Solid,>54°C Liquid
Color White to light yellow
SMILES

[Petrolatum (white)]
別名

ペトロラタム白色
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016;87:88-99. [Content Brief]

[2]. Ghadially R, et al. Effects of petrolatum on stratum corneum structure and function[J]. Journal of the American Academy of Dermatology, 1992, 26(3): 387-396.

[3]. Czarnowicki T, et al. Petrolatum: Barrier repair and antimicrobial responses underlying this "inert" moisturizer. J Allergy Clin Immunol. 2016;137(4):1091-1102.e7. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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