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製品番号: HY-183371

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ZINC13407541

ZINC13407541 is a fibroblast growth factor 23 (FGF23) antagonist with an IC₅₀ of 0.45 μM. ZINC13407541 preferentially binds to the FGF23:FGFR interface to disrupt their protein-protein interactions. ZINC13407541 can be used for the research of hypophosphatemia.

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CAS 番号: 864868-22-4
分子式: C₁₄H₁₅NO
分子量:213.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZINC13407541 構造式

CAS 番号: 864868-22-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	EC₅₀	1.41 10^3 μM Compound: 1; ZINC13407541	Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay	[PMID: 33232874]

体外実験

ZINC13407541 acts as an FGF23 antagonist with an IC₅₀ of 0.45 μM^[1].
ZINC13407541 can bind to the non-FGFR-interacting distal pocket of FGF23_Nterm, but also reveals it can bind to the predicted FGF23:FGFR protein-protein interaction region^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 864868-22-4
分子量 213.28
分子式 C₁₄H₁₅NO
SMILES

O/N=C/C1=C(CCC1)/C=C/C2=CC=CC=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Velazquez HA, et al. Ensemble docking to difficult targets in early-stage drug discovery: Methodology and application to fibroblast growth factor 23. Chem Biol Drug Des. 2018;91(2):491-504. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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