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DERL3 - derlin 3 Gene

Also Known as IZP6; LLN2; C22orf14; derlin-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91319

About DERL3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,834,503-23,839,006 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 176 orthologues and 2 paralogues. Broad expression in stomach (RPKM 12.2), duodenum (RPKM 11.1) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

DERL3 Products (4)

mRNA	Protein	Name
NM_001002862.3	NP_001002862.1	derlin-3 isoform 2
NM_001135751.2	NP_001129223.1	derlin-3 isoform 1
NM_001363072.2	NP_001350001.1	derlin-3 isoform 4
NM_198440.4	NP_940842.2	derlin-3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16449189	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	26565908	GOA
enables signal recognition particle binding	IDA IDA: Inferred from direct assay	26565908	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	16449189	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	22607976	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	16449189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DERL3 Protein Structure

DER1

0
100
200
235 a.a.

Protein Preferred Names	Protein Names
derlin-3	DERtrin 3

DERL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DERL3	Q96Q80	TMEM92	Homo sapiens	Q6UXU6	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	TMEM92	Homo sapiens	Q6UXU6	Y2H Array	32296183
Intra	DERL3	Q96Q80	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	DERL3	Q96Q80	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	DERL3	Q96Q80	RTP4	Homo sapiens	Q96DX8	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	RTP4	Homo sapiens	Q96DX8	Y2H Array	32296183
Intra	DERL3	Q96Q80	SLC13A4	Homo sapiens	Q9UKG4	Validated Y2H	32296183
Intra	DERL3	Q96Q80	SLC13A4	Homo sapiens	Q9UKG4	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	SLC13A4	Homo sapiens	Q9UKG4	Y2H Array	32296183
Intra	DERL3	Q96Q80	GNLY	Homo sapiens	P22749	Y2H Array	32296183
Intra	DERL3	Q96Q80	GNLY	Homo sapiens	P22749	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	GPR101	Homo sapiens	Q96P66	Y2H Array	32296183
Intra	DERL3	Q96Q80	GPR101	Homo sapiens	Q96P66	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183
Intra	DERL3	Q96Q80	IL27RA	Homo sapiens	Q6UWB1	Y2H Array	32296183
Intra	DERL3	Q96Q80	IL27RA	Homo sapiens	Q6UWB1	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	EHHADH	Homo sapiens	Q08426	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	ULBP2	Homo sapiens	Q9BZM5	Y2H Prey Pooling	32296183
Intra	DERL3	Q96Q80	ULBP2	Homo sapiens	Q9BZM5	Validated Y2H	32296183
Intra	DERL3	Q96Q80	ULBP2	Homo sapiens	Q9BZM5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169003	STT3A/B-IN-1	Inhibitor	99.15%	Unkown
HY-RS03701	DERL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DERL3	VGNC	VGNC:71622
Mus musculus	DERL3	MGD	MGI:1917627
Rattus norvegicus	DERL3	RGD	RGD:1597373
Bos taurus	DERL3	VGNC	VGNC:28012
Felis catus	DERL3	VGNC	VGNC:61450
Canis familiaris	DERL3	VGNC	VGNC:39904
Others	DERL3	NCBI