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GNLY - granulysin Gene

Also Known as LAG2; NKG5; LAG-2; D2S69E; TLA519

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10578

About GNLY

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,694,358-85,698,852 (from NCBI)

This gene has 14 transcripts (splice variants) and 50 orthologues. Biased expression in bone marrow (RPKM 67.6), endometrium (RPKM 42.4) and 5 other tissues.

Summary

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and Other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GNLY Products (3)

mRNA	Protein	Name
NM_001302758.2	NP_001289687.1	granulysin isoform 1 precursor
NM_006433.5	NP_006424.2	granulysin isoform 2 precursor
NM_012483.4	NP_036615.2	granulysin isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	9756476	GOA
involved in cellular defense response	IDA IDA: Inferred from direct assay	9756476	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	9756476	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	9756476	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with cytolytic granule	IDA IDA: Inferred from direct assay	9756476	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNLY Protein Structure

SapB_2

0
100
145 a.a.

Protein Preferred Names	Protein Names
granulysin	T-cell activation protein 519

GNLY Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GNLY	P22749	DERL3	Homo sapiens	Q96Q80	Validated Y2H	32296183
Intra	GNLY	P22749	BCL2L1	Homo sapiens	Q07817	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Erythema Multiforme	Dermatostomatitis, Erythema Multiforme Type Em Erythema Multiforme Bullosum Erythema Polymorphe, Erythema Multiforme Type Febrile Mucocutaneous Syndrome Herpes Iris, Erythema Multiforme Type Stevens-Johnson Syndrome Em - [Erythema Multiforme]
Kyphoscoliotic Heart Disease
Folliculitis
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Erythematosquamous Dermatosis	Other Erythematosquamous Dermatosis
Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Drug-Induced Stevens Johnson Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Susceptibility To Severe Cutaneous Adverse Reaction Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Lyell'S Syndrome Lyell Syndrome Severe Cutaneous Adverse Reaction, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced Stevens-Johnson Syndrome, Susceptibility To Toxic Epidermal Necrolysis, Susceptibility To Sjs/Ten Susceptibility To Severe Cutaneous Adverse Reaction Ity To Mycoplasma-Induced Stevens Johnson Syndrome Dermatostomatitis, Stevens Johnson Type Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum Sjs-Ten Toxic Epidermolysis SJS Dermatostomatitis Stevens Johnson Type Ten Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis] Ten - [Toxic Epidermal Necrolysis]
Phenytoin Allergy	Dilantin Allergy
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1	Cadasil Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Casil Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Familial Vascular Leukoencephalopathy CADASIL1 Cadasil 1 Hereditary Multi-Infarct Dementia Cadasil Syndrome Dementia, Hereditary Multiinfarct Type Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1 Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1 Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy Dementia, Hereditary Multi-Infarct Type Hereditary Dementia, Multi-Infarct Type Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1 Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant Dementia Hereditary Multiinfarct Type Dementia Hereditary Multi-Infarct Type Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Ceftazidime Allergy	Fortaz Allergy Tazicef Allergy
Spondylocostal Dysostosis	Jarcho-Levin Syndrome Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylothoracic Dysplasia Scdo Dysostosis, Spondylocostal
Tick Paralysis
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150177	Mannose 6 phosphate		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110266	GN44028	Inhibitor	99.60%	Unkown
HY-117280	GN25	Activator	98.55%	Unkown
HY-P5309	IgA1 Peptide GN5		/	Unkown
HY-163338	Metallo-β-lactamase-IN-13	Inhibitor	/	Unkown
HY-163339	Metallo-β-lactamase-IN-14	Inhibitor	/	Unkown
HY-183351	GN-604		/	Unkown
HY-P11657	GN-2 peptoid	Inhibitor	/	Unkown
HY-P2082	[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH	Agonist	/	Unkown
HY-P5309A	IgA1 Peptide GN5 TFA		/	Unkown
HY-RS05568	GNLY Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991482	ADI-42898	Inhibitor	/	Unkown