Apbb1 - amyloid beta (A4) precursor protein-binding, family B, member 1 Gene

Also Known as Rir; Fe65

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11785

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including double-strand break repair; positive regulation of DNA repair; and smooth muscle contraction. Acts upstream of or within several processes, including generation of neurons; negative regulation of neuron differentiation; and visual learning. Located in cytoplasm and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human APBB1 (amyloid beta precursor protein binding family B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Apbb1 Products (11)

mRNA	Protein	Name
NM_001253885.2	NP_001240814.1	amyloid beta precursor protein binding family B member 1 isoform 1
NM_001253886.2	NP_001240815.1	amyloid beta precursor protein binding family B member 1 isoform 2
NM_001253887.2	NP_001240816.1	amyloid beta precursor protein binding family B member 1 isoform 3
NM_001310600.2	NP_001297529.1	amyloid beta precursor protein binding family B member 1 isoform 4
NM_001411958.1	NP_001398887.1	amyloid beta precursor protein binding family B member 1 isoform 2
NM_001411959.1	NP_001398888.1	amyloid beta precursor protein binding family B member 1 isoform 5
NM_001411960.1	NP_001398889.1	amyloid beta precursor protein binding family B member 1 isoform 5
NM_001411961.1	NP_001398890.1	amyloid beta precursor protein binding family B member 1 isoform 5
NM_001411962.1	NP_001398891.1	amyloid beta precursor protein binding family B member 1 isoform 5
NM_001411964.1	NP_001398893.1	amyloid beta precursor protein binding family B member 1 isoform 6
NM_009685.4	NP_033815.1	amyloid beta precursor protein binding family B member 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8894693	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25342469	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	17121854	MGI
acts upstream of or within axon guidance	IGI IGI: Inferred from genetic interaction	16407979	MGI
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	17121854	MGI
acts upstream of or within extracellular matrix organization	IGI IGI: Inferred from genetic interaction	16407979	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18278038	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18278038	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	16407979	MGI
involved in positive regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	17121854	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15944124	MGI
involved in smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	25757569	MGI
involved in synapse organization	IDA IDA: Inferred from direct assay	27734846	MGI
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	27734846	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	27734846	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	27734846	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17121854	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27734846	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27734846	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	27734846	MGI
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	27734846	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17121854	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
amyloid beta precursor protein binding family B member 1 amyloid-beta A4 precursor protein-binding family B member 1

Protein Preferred Names

Protein Names

amyloid beta precursor protein binding family B member 1

amyloid-beta A4 precursor protein-binding family B member 1

Apbb1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Apbb1	Q9QXJ1	App	Mus musculus	P12023	Pull Down	11517249
Intra	Apbb1	Q9QXJ1	App	Mus musculus	P12023	Y2H	11517249

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS00804	APBB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00805	APBB1IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apbb1	NCBI	NCBI:322